{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:53:31Z","timestamp":1785365611908,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006122","name":"Deutsche Ophthalmologische Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The German retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>) Registry collects data on treated <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in a multicentre approach to analyse epidemiology and treatment patterns of severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine centres entered data from 90 treated <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> infants (born between January 2011 and December 2013) into a central database. Analysis included incidence rate of severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, demographic data, stage of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, treatment patterns, recurrence rates, relevant comorbidities and ophthalmological or systemic complications associated with treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment rate for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> was 3.2% of the screened population. The most frequent <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> stage at time of treatment was zone <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, stage 3\u00a0+\u00a0 (137 eyes). Treatment was bilateral in 97% of infants. Treatment patterns changed over time from 7% anti\u2010vascular endothelial growth factor (VEGF) monotherapy in 2011 to 32% in 2014. Overall, laser treatment was the predominant treatment. However, all infants with zone I disease received anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> treatment. About 19% of infants required retreatment (16% of laser\u2010treated and 21% of anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> treated infants). Mean time between first and second treatment was 3.8\u00a0weeks (\u00b1\u00a011\u00a0days) for laser\u2010treated and 10.4\u00a0weeks (\u00b1 60\u00a0days) for anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010treated infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is the first multicentre analysis of severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in Germany. The identified treatment patterns find laser as the most prevalent form of therapy, with an increasing use of anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> therapy over recent years. Recurrence rates were relatively high overall with slightly higher recurrence rates and later recurrence times in the anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> group. Anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> was predominantly used for high\u2010risk stages like <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> and zone I disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13069","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T15:37:39Z","timestamp":1463845059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The German ROP Registry: data from 90 infants treated for retinopathy of prematurity"],"prefix":"10.1111","volume":"94","author":[{"given":"Johanna M.","family":"Walz","sequence":"first","affiliation":[{"name":"Eye Center University of Freiburg Freiburg Germany"},{"name":"Department of Pharmacology and Toxicology University of Regensburg Regensburg 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