{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:02:21Z","timestamp":1769756541175,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY\u20101576"],"award-info":[{"award-number":["EY\u20101576"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore associations of lamina cribrosa thickness with axial length and thickness of the posterior sclera in monkeys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Examining histological sections by light microscopy, we measured the thickness of the lamina cribrosa and posterior sclera and axial length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 28 animals (28 eyes) with a mean age of 13.3\u00a0\u00b1\u00a04.9\u00a0years (range: 3\u201324\u00a0years) and mean axial length of 18.9\u00a0\u00b1\u00a01.4\u00a0mm (range: 17\u201321\u00a0mm) (22 eyes after experimental temporary central retinal artery occlusion; four eyes after a permanent occlusion of the posterior ciliary artery; and two eyes without any intervention). Mean thickness of the lamina cribrosa was 167\u00a0\u00b1\u00a030\u00a0<jats:italic>\u03bc<\/jats:italic>m (range: 115\u2013273\u00a0<jats:italic>\u03bc<\/jats:italic>m). Thinner lamina cribrosa thickness was significantly associated with longer axial length (standardized correlation coefficient beta: \u20100.42; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026), with thinner sclera at the posterior pole (beta: 0.56; p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.002) and with thinner sclera at the disc border (beta: 0.55; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002). Lamina cribrosa thickness was not significantly related to temporary central retinal artery occlusion (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.14) or to permanent posterior ciliary artery occlusion (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.49) or age (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As in humans, lamina cribrosa thickness in non\u2010glaucomatous monkeys got thinner with longer axial length and with thinner posterior sclera. These data may be of interest for studies on the process of emmetropization\/myopization in monkeys, and they may be of interest for the studies on the biomechanics of the optic nerve head.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13070","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T05:25:45Z","timestamp":1462771545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lamina cribrosa thickness correlated with posterior scleral thickness and axial length in monkeys"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan N.","family":"Kutscher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohan S.","family":"Hayreh","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology and Visual Sciences College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.06.002"},{"issue":"5","key":"e_1_2_5_3_1","first-page":"6","article-title":"The anatomy and pathophysiology of the optic nerve head in glaucoma","volume":"10","author":"Burgoyne CF","year":"2001","journal-title":"J Glaucoma"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12809"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3363"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3113682"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040459019"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.12.896"},{"key":"e_1_2_5_9_1","first-page":"2296","article-title":"Parapapillary chorioretinal atrophy in chronic high\u2010pressure experimental glaucoma in rhesus monkeys","volume":"39","author":"Hayreh SS","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.047"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0851"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00164650"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0174"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1363"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.243"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02121.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02088.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047237"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11352"},{"key":"e_1_2_5_20_1","article-title":"Lamina cribrosa defects in eyes with glaucomatous disc haemorrhage","author":"Kim YK","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1429"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1369-y"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1792"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0541"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029692"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.048"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.050"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0349"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:48:27Z","timestamp":1695574107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/aos.13070"],"URL":"https:\/\/doi.org\/10.1111\/aos.13070","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,9]]},"assertion":[{"value":"2015-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}