{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:01:28Z","timestamp":1774360888663,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report our 4\u2010year experience in Turkey, with advanced intra\u2010ocular retinoblastoma managed primarily with intra\u2010arterial chemotherapy (<jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2011 to September 2015, 26 group D eyes of 24 treatment\u2010na\u00efve retinoblastoma patients managed primarily with <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content> were evaluated in this prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 76 procedures, ophthalmic artery cannulation failed in two patients with unilateral involvement. In the remaining 22 patients (24 eyes), the mean age at diagnosis was 18\u00a0months (range, 6\u201355\u00a0months). Each eye received a mean of 3 <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content> sessions\/eye (range, 2\u20135 sessions). After a median follow\u2010up of 29\u00a0months (range, 6\u201355\u00a0months), complete regression of the main tumour was achieved in 23 of 24 eyes. One eye with partial regression required enucleation due to ciliary body involvement by the tumour. Overall, 16 eyes (66.6%) were salvaged with primary <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content> with or without additional local treatments, and eight (33.3%) required enucleation. The main <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\u2010related periocular complications included transient eyelid oedema (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), ptosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and forehead hyperpigmentation (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), each resolving in 2\u00a0weeks to 4\u00a0months. Intra\u2010ocular complications included chorioretinal atrophy (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), newly noted retinal detachment (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) and vitreous haemorrhage (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Kaplan\u2013Meier eye estimates of enucleation\u2010free survival rates were 83.3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 68.4\u201398.1%), 69.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 49.8\u201388.3%) and 62.9 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 41.9\u201383.8%) at 6\u00a0months, 1 and 2\u00a0years, respectively, and stable thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our first 4\u2010year experience in Turkey showed that enucleation or external\u2010beam radiotherapy could be avoided in two\u2010thirds of eyes with advanced intra\u2010ocular retinoblastoma managed primarily with <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13077","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T14:23:00Z","timestamp":1464099780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Superselective intra\u2010arterial chemotherapy in the primary management of advanced intra\u2010ocular retinoblastoma: first 4\u2010year experience from a single institution in Turkey"],"prefix":"10.1111","volume":"94","author":[{"given":"Samuray","family":"Tuncer","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Ophthalmology Ocular Oncology Service Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serra","family":"Sencer","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Radiology Division of Interventional 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