{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:41:41Z","timestamp":1767908501584,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Defence MINDEF, Singapore"},{"name":"Singapore Ministry of Education, Academic Research Fund, Tier 1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the influence of choroidal thickness (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) on visual acuity (<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>) in young persons with extremely high myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2013control study of young men with extremely high myopia and controls with emmetropia recruited from a mandatory medical eye review for employment purposes. Retinal and choroidal imaging was performed using enhanced depth imaging (<jats:styled-content style=\"fixed-case\">EDI<\/jats:styled-content>) spectral\u2010domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 105 extremely high myopic subjects with spherical equivalent (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) \u201010 dioptre (D) or worse and 50 emmetropic subjects with <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> less than 0.5 D. The mean <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> was \u221211.56\u00a0\u00b1\u00a02.04 D (range, \u221210 to \u221223 D) for myopic group and 0.14\u00a0\u00b1\u00a00.25 D for emmetropic group. The mean age of included myopic and emmetropic subjects was 21.51\u00a0\u00b1\u00a01.22\u00a0years and 21.96\u00a0\u00b1\u00a00.89\u00a0years, respectively. In the univariate analysis, subfoveal <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was significantly associated with best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) (<jats:italic>\u03b2\u00a0<\/jats:italic>=\u00a0\u22120.039, p\u00a0=\u00a00.015). However, in the multiple linear regression analysis, after adjusting for <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> and presence of any pathological myopia lesions such as posterior staphyloma, lacquer cracks or chorioretinal atrophy, subfoveal <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was not independently associated with <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> (p\u00a0=\u00a00.937).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extremely high myopic eyes had thinner choroid, but <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was not an independent predictor of <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>. Other factors related to myopia are likely responsible for the diminished <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> in young extremely high myopic eyes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13084","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T18:28:53Z","timestamp":1463682533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Choroidal thickness does not predict visual acuity in young high myopes"],"prefix":"10.1111","volume":"94","author":[{"given":"Preeti","family":"Gupta","sequence":"first","affiliation":[{"name":"Singapore Eye Research Institute and Singapore National Eye Centre Singapore Singapore"},{"name":"Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Y.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute and Singapore National Eye Centre Singapore Singapore"},{"name":"Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seang\u2010Mei","family":"Saw","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute and Singapore National Eye Centre Singapore Singapore"},{"name":"Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore Singapore 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