{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:02Z","timestamp":1790856722775,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26462689"],"award-info":[{"award-number":["26462689"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to elucidate the relationship between visual field defects in the upper and lower hemifields and the corresponding oxygen saturation of the retinal vessels in patients with glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with glaucoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a044) exhibiting more than a 10\u00a0<jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content> difference between the upper and lower total deviation (<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>) were enrolled in the study. After measuring the retinal vessel oxygen saturation by a non\u2010invasive spectrophotometric retinal oximeter, the hemifields in one eye of each patient were divided into worse (worse <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>) and better (better <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>) hemifield areas. We additionally evaluated a separate group of 40 patients with glaucoma who exhibited less than a 5\u00a0<jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content> difference between the upper and lower <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>. Statistical analysis was performed using a Student's <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher mean venous saturation of oxygen (SaO<jats:sub>2<\/jats:sub>) was observed in the worse (59.0\u00a0\u00b1\u00a08.0%) hemifield compared to the better (55.4\u00a0\u00b1\u00a07.2%) hemifield (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). The mean arteriovenous difference in the SaO<jats:sub>2<\/jats:sub> was lower in the worse (44.4\u00a0\u00b1\u00a09.0%) hemifield compared to the better (48.6\u00a0\u00b1\u00a011.4%) hemifield (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). However, when we evaluated the worse and better hemifields in the patients who had less than a 5\u00a0<jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content> difference in the upper and lower hemifield <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>, we found no statistically significant differences for either the retinal SaO<jats:sub>2<\/jats:sub> in the venous vessels or the arteriovenous difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advanced glaucomatous visual field defects were associated with increased SaO<jats:sub>2<\/jats:sub> in the venous vessels and a decreased arteriovenous difference in the SaO<jats:sub>2<\/jats:sub>. The present results suggest there is a reduced retinal oxygen extraction in eyes with glaucomatous damage due to retinal ganglion cell loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13089","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T12:31:18Z","timestamp":1464265878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield"],"prefix":"10.1111","volume":"94","author":[{"given":"Takeru","family":"Shimazaki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Ukegawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitaka","family":"Tsujikawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Kagawa University Miki Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00138-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00964-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199906000-00012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9912"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000156134.38495.0b"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2976032"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5537"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00018-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126179"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6985"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303162"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030137016"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90488-1"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01167.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.125187"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.148460"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12011"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13089","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Faos.13089","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:49:33Z","timestamp":1695574173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/aos.13089"],"URL":"https:\/\/doi.org\/10.1111\/aos.13089","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]},"assertion":[{"value":"2015-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}