{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:48:20Z","timestamp":1788392900915,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500677"],"award-info":[{"award-number":["81500677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To identify the prevalence of dry eye in pediatric population with allergic conjunctivitis in Southwest China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre, prospective, case\u2013control study conducted between May 2015 and December 2015 included 40 children, 3\u20136\u00a0years of age, with seasonal allergic conjunctivitis (SAC) or perennial allergic conjunctivitis (PAC) and 40 age\u2010 and gender\u2010matched children undergoing medical healthy examination without history of allergy or dry eye as a control. A dry eye score system (DESS) was administered to both groups. Slit\u2010lamp examinations including tear film break\u2010up time (TFBUT) and fluorescent corneal staining (FCS) were performed. Correlation analyses were performed to evaluate associations between measures of dry eye and signs and symptoms of AC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of dry eye was 97.5% (78\/80 eyes) in cases and 27.50% (22\/80 eyes) in controls. Mean DESS score was 4.75\u00a0\u00b1\u00a02.22 in the case group and 0.80\u00a0\u00b1\u00a01.22 in the control group (p\u00a0&lt;\u00a00.001). Symptoms of dry eye in the case group were mild (&lt;6). Mean tear film break\u2010up time was 6.54\u00a0\u00b1\u00a01.48\u00a0seconds in the case group and 10.04\u00a0\u00b1\u00a01.79\u00a0seconds in the control group (p\u00a0&lt;\u00a00.001). Mean FCS scores were 0.79\u00a0\u00b1\u00a01.34 and 0.21\u00a0\u00b1\u00a00.57, respectively (p\u00a0=\u00a00.001). The DESS score and TFBUT were both associated with the duration of allergic conjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of dry eye assessed by TFBUT was higher in young children with SAC and PAC than in controls. However, subjective symptoms of dry eye (DESS) were inconsistent with objective signs, indicating that close attention should be paid to the evaluation and treatment of dry eye in pediatric population with AC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13093","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T12:04:39Z","timestamp":1464264279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["High incidence of dry eye in young children with allergic conjunctivitis in Southwest China"],"prefix":"10.1111","volume":"94","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhong","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Children's Hospital 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