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We critically reviewed the current literature surrounding <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> and recent imaging technology as well as histology. Primary searches of PubMed and Web of Science were performed. We reviewed all papers on the topic published and summarized the findings of each medical device as well as the advantages and disadvantages of using these for the <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> patient. We discussed the potential of each of these devices to monitor potential ocular pathology in the <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> cohorts in the order of <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> subtype. We reviewed imaging techniques involving use of the Iris Camera, Pentacam, Optical Coherence Tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) as well as ultrasound and Heidelberg <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. The need for reliable objective quantification of eye findings in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> has led to utilization of new imaging technologies described here, and future use will enhance our understanding of the unique eye features in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>. In particular, we note that the Pentacam and iris camera are able to provide objective measurements of corneal haze and monitor ocular response to treatment.<\/jats:p>","DOI":"10.1111\/aos.13098","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T11:54:31Z","timestamp":1465386871000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Use of new imaging in detecting and monitoring ocular manifestations of the mucopolysaccharidoses"],"prefix":"10.1111","volume":"94","author":[{"given":"Ahmed","family":"Javed","sequence":"first","affiliation":[{"name":"Manchester Royal Eye Hospital Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Aslam","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital Manchester Academic Health Science Centre Manchester UK"},{"name":"Faculty of 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