{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:52Z","timestamp":1790633392021,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001064"],"award-info":[{"award-number":["UL1TR001064"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non\u2010arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective, case\u2013control study of 44 patients (50 eyes) with ON or NAION and 44 age\u2010matched controls. Non\u2010arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow\u2010up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time\u2010point using unpaired <jats:italic>t<\/jats:italic>\u2010tests and between disease and control subjects at first measurement using paired <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean time from onset of symptoms to initial presentation was 10.7\u00a0\u00b1\u00a06.6\u00a0days in NAION and 11.7\u00a0\u00b1\u00a08.6\u00a0days in ON (p\u00a0=\u00a00.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time\u2010points (5.5\u201310.7\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 3.1\u20133.6\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0=\u00a00.01\u20130.049). Mean GCC thickness was significantly decreased at less than 2\u00a0weeks after onset in NAION compared to age\u2010matched controls (72.1\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 82.1\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0&lt;\u00a00.001), as well as in ON compared to age\u2010matched controls (74.3\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 84.5\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0&lt;\u00a00.001). Progression and severity of GCC and RNFL loss did not differ significantly between NAION and ON.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A quantitative comparison of mean superior and inferior hemispheric GCC thickness with OCT may be used to distinguish NAION from ON.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13128","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T05:07:45Z","timestamp":1467349665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis"],"prefix":"10.1111","volume":"94","author":[{"given":"Natalie","family":"Erlich\u2010Malona","sequence":"first","affiliation":[{"name":"New England Eye Center Tufts University School of Medicine Tufts Medical Center Boston Massachusetts 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