{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:27:12Z","timestamp":1788827232044,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14401931400"],"award-info":[{"award-number":["14401931400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To evaluate the meibomian gland function, morphology and the related medical history of patients with blepharokeratoconjunctivitis (BKC<\/jats:styled-content>) in comparison with healthy population and meibomian gland dysfunction (MGD<\/jats:styled-content>)\u2010induced evaporative dry eye (EDE<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010two eyes of 22 Asian adult patients with BKC<\/jats:styled-content> were enrolled as the BKC<\/jats:styled-content> group. Healthy volunteers and MGD<\/jats:styled-content>\u2010induced EDE<\/jats:styled-content> patients were recruited in a 1:1 ratio and were matched in age, and the gender compositions of the three groups were also comparable. Examinations included meibum quality, meibomian gland expressibility, meibomian gland dropout and relevant ocular surface tests. Related medical history was recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>The BKC<\/jats:styled-content> group had higher incidences of chalazion (OR<\/jats:styled-content> 4.59, 95% CI<\/jats:styled-content> 1.29\u201316.33) and eyelid surgery (OR<\/jats:styled-content> 4.91, 95% CI<\/jats:styled-content> 1.33\u201318.21) than the control group (chalazion, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007; eyelid surgery, p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and EDE<\/jats:styled-content> group (chalazion, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.031; eyelid surgery, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005) had. All clinical indexes were worse in the BKC<\/jats:styled-content> group than in the control group (all p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). The EDE<\/jats:styled-content> group had better meibum quality (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.049) and less meibomian gland dropouts (all p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05) than the BKC<\/jats:styled-content> group. The dropouts of the BKC<\/jats:styled-content> group were the highest among the three groups, and the distribution over the tarsal plate was even in the BKC<\/jats:styled-content> group (all p\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with BKC<\/jats:styled-content> had worse meibomian gland function, poorer morphology and a higher rate of medical histories related to the meibomian gland than the healthy population. The BKC<\/jats:styled-content> clinical features of meibum quality and meibomian gland dropout were different from other MGD<\/jats:styled-content> diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13136","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T11:35:29Z","timestamp":1465385729000},"page":"634-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The evaluation of meibomian gland function, morphology and related medical history in Asian adult blepharokeratoconjunctivitis patients"],"prefix":"10.1111","volume":"95","author":[{"given":"Yue","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Science The Eye & ENT Hospital of Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science The Eye & ENT Hospital of Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Shanghai 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