{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:27:57Z","timestamp":1776338877781,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271027"],"award-info":[{"award-number":["81271027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the differential aqueous concentrations of vascular endothelia growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) and inflammatory cytokines in paediatric and adult patients with Coats' disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20 eyes of 20 patients with Coats' disease, 12 eyes of 12 paediatric patients, and eight eyes of eight adult patients, six patients (six eyes) with congenital cataract as the paediatric control group and 10 patients (10 eyes) with senile cataract as the adult control group were examined. Aqueous humour samples were assessed for interleukin\u20106, \u20108, \u20101<jats:italic>\u03b2<\/jats:italic> (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>, respectively), basic fibroblast growth factor, monocyte chemo\u2010attractant protein 1, tumour necrosis factor alpha and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> by multiplex bead assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly, higher concentrations of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> were found in the paediatric patients with Coats' disease (p\u00a0=\u00a00.001, p\u00a0=\u00a00.004 and p\u00a0=\u00a00.006). Concentration of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> in the paediatric patients with Stage 3B of Coats' disease was significantly higher than that of Stage 3A (p\u00a0=\u00a00.010). In the adult patients with Coats' disease, the aqueous levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> were significantly higher than that of the controls (p\u00a0=\u00a00.012, and p\u00a0=\u00a00.005). The concentration of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 was significantly linearly associated with the extent of exudative retinal detachment (p\u00a0=\u00a00.003, <jats:italic>R<\/jats:italic>\u00a0=\u00a00.892).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing severity of Coats' disease is significantly associated with intraocular <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> concentration in the paediatric patients. And <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 may be involved with the inflammatory process in the adult patients with Coats' disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13151","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T04:55:28Z","timestamp":1467348928000},"page":"608-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Differences in aqueous concentrations of cytokines in paediatric and adult patients with Coats' disease"],"prefix":"10.1111","volume":"95","author":[{"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology People's Hospital Peking University and Key Laboratory of Vision Loss and Restoration Ministry of Education and Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases Beijing China"},{"name":"Department of Ophthalmology People's Liberation Army (PLA) Rocket Forces General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology People's Hospital Peking University and Key Laboratory of Vision Loss and Restoration Ministry of Education and Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology People's Hospital Peking University and Key Laboratory of Vision Loss and Restoration Ministry of Education and Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanrong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology People's Hospital Peking University 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