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Control groups (oxygen\u2010induced retinopathy group: 12 C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice; diabetic retinopathy group: 15 rats; retinal ischaemia\u2013reperfusion model: 18 rats) received an intravitreal injection of phosphate\u2010buffered saline. We applied immunohistological techniques to measure retinal vascularization, spectroscopic measurements of intraretinally extravasated fluorescein\u2010conjugated dextran to quantify the blood\u2013retina barrier breakdown, and histomorphometry to assess retinal thickness and retinal ganglion cell count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the oxygen\u2010induced retinopathy model, the study group with intravitreally injected <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s as compared with the control group showed a significantly (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) smaller area of retinal neovascularization. In the diabetic retinopathy model, study group and control group did not differ significantly in the amount of intraretinally extravasated dextran. In the retinal ischaemia\u2013reperfusion model, on the 7th day after retina injury, the retina was significantly thicker in the study group than in the control group (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), with no significant difference in the retinal ganglion cell count (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravitreally implanted human <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s were associated with a reduced retinal neovascularization in the oxygen\u2010induced retinopathy model and with a potentially cell preserving effect in the retinal ischaemia\u2013reperfusion model. Intravitreal <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s may be of potential interest for the therapy of retinal vascular disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13154","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T07:43:04Z","timestamp":1478158984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Human bone marrow mesenchymal stem cells for retinal vascular injury"],"prefix":"10.1111","volume":"95","author":[{"given":"Jin\u2010Da","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital of Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"An","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital of Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Shang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital of Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Hua","family":"Wan","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital of Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost 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