{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:27:04Z","timestamp":1792268824196,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T00:00:00Z","timestamp":1470441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate central and peripheral corneal endothelial cell density (<jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content>) in relation to Baerveldt (<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>) glaucoma drainage device (<jats:styled-content style=\"fixed-case\">GDD<\/jats:styled-content>) tube corneal (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>) distance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of all patients scheduled for glaucoma tube surgery with 36\u00a0months follow\u2010up. A <jats:styled-content style=\"fixed-case\">BV GDD<\/jats:styled-content> was inserted into the anterior chamber (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>). Anterior segment optical coherence tomography (AS\u2010OCT) scans were made to determine the <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distance. Central and peripheral <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> was measured, preoperatively and at 3, 6, 12, 24 and 36\u00a0months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three eyes were included [primary open\u2010angle glaucoma, (<jats:italic>n<\/jats:italic>\u00a0=\u00a013); secondary glaucoma, (<jats:italic>n<\/jats:italic>\u00a0=\u00a030); and primary angle\u2010closure glaucoma, (<jats:italic>n<\/jats:italic>\u00a0=\u00a010)]. Central <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> significantly decreased during follow\u2010up, with a mean decrease of 4.54% per year (p\u00a0&lt;\u00a00.001), and 6.57% in the peripheral quadrant closest to the <jats:styled-content style=\"fixed-case\">BV GDD<\/jats:styled-content> tube (<jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content>, p\u00a0&lt;\u00a00.001). In the <jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content>, a yearly decrease of 1.57% was shown after transiridial tube placement versus 7.43% after placement \u2018free\u2019 into the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> (p\u00a0=\u00a00.006). Endothelial cell (EC) loss was related to <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distance (mean 1.69\u00a0mm), with a central loss of 6.20% and 7.25% in the <jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content> per year with shorter <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distances, versus a central loss of 4.11% and 5.77% in the <jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content> per year with longer <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distances (outside mean\u00a0\u00b1\u00a02<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, p\u00a0&lt;\u00a00.001). A difference in <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> loss by glaucoma subtype was not identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distance is of significant influence on corneal <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content>, a shorter <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> distance causing more severe <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> loss, especially in the <jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content>. Transiridial placement of the <jats:styled-content style=\"fixed-case\">BV GDD<\/jats:styled-content> tube seems safer than placement \u2018free\u2019 into the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13161","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T12:14:48Z","timestamp":1470485688000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Corneal endothelial cell loss after Baerveldt glaucoma drainage device implantation in the anterior chamber"],"prefix":"10.1111","volume":"95","author":[{"given":"Annelie N.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center Leiden The Netherlands"},{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll A. B.","family":"Webers","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tos T. J. M.","family":"Berendschot","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"de Brabander","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"de Witte","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy M. M. A.","family":"Nuijts","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes S. A. G.","family":"Schouten","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny J. M.","family":"Beckers","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center University Eye Clinic Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"779","article-title":"Central corneal endothelial cell changes over a ten\u2010year period","volume":"38","author":"Bourne WM","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4759"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3981"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12274"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199705000-00010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.07.022"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.024"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.026"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328325a54b"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01683.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000110"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000301"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.016"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73530-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.321"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.03.031"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.03.033"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.02.013"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000379"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00080-X"},{"key":"e_1_2_5_22_1","first-page":"816","article-title":"Evidence suggesting the existence of stem cells for the human corneal endothelium","volume":"11","author":"Whikehart DR","year":"2005","journal-title":"Mol Vis"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13161","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:06:59Z","timestamp":1695481619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,6]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/aos.13161"],"URL":"https:\/\/doi.org\/10.1111\/aos.13161","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,6]]},"assertion":[{"value":"2015-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}