{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:13:11Z","timestamp":1788862391004,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:00:00Z","timestamp":1471046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Comparison of the efficacy of tropicamide eyedrops to the combination of 0.5% tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized, double\u2010blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% tropicamide (<jats:styled-content style=\"fixed-case\">TTT<\/jats:styled-content> regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0.5% tropicamide (<jats:styled-content style=\"fixed-case\">PTT<\/jats:styled-content> regimen). Thirty premature infants were enrolled and received both mydriatic regimens: one regimen in each eye. Outcomes were pupil dilation evaluated by the percentage of pupil diameter over cornea diameter, the percentage of pupil surface over cornea surface and the quality of the eye fundus examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of pupil diameter over cornea diameter was 47.3% (\u00b18.7) with the <jats:styled-content style=\"fixed-case\">TTT<\/jats:styled-content> regimen and 65.9% (\u00b18.8) with the <jats:styled-content style=\"fixed-case\">PTT<\/jats:styled-content> regimen (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). The percentage of pupil surface over cornea surface was 23.1% (\u00b18.3) with the <jats:styled-content style=\"fixed-case\">TTT<\/jats:styled-content> regimen and 43.8% (\u00b17.3) with the <jats:styled-content style=\"fixed-case\">PTT<\/jats:styled-content> regimen (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Thus, the pupil surface area was 1.9 times greater with the <jats:styled-content style=\"fixed-case\">PTT<\/jats:styled-content> than with the <jats:styled-content style=\"fixed-case\">TTT<\/jats:styled-content> regimen. Visualization of the retinal periphery was possible for 30 of 30 eyes dilated with the <jats:styled-content style=\"fixed-case\">PTT<\/jats:styled-content> regimen and for 16 of 30 eyes dilated with the <jats:styled-content style=\"fixed-case\">TTT<\/jats:styled-content> regimen (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The dilated pupil surface area for the combination of 5% phenylephrine and 0.5% tropicamide was almost twice that for 0.5% tropicamide eyedrops alone and provided significantly superior quality of the eye fundus examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13175","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T05:42:22Z","timestamp":1471066942000},"page":"165-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Combination of 5% phenylephrine and 0.5% tropicamide eyedrops for pupil dilation in neonates is twice as effective as 0.5% tropicamide eyedrops alone"],"prefix":"10.1111","volume":"95","author":[{"given":"Anne\u2010Laure","family":"Lux","sequence":"first","affiliation":[{"name":"Medical School Unicaen, PFRS Caen Cedex France"},{"name":"Department of Ophthalmology Caen University Hospital Center Caen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Degoumois","sequence":"additional","affiliation":[{"name":"Medical School Unicaen, PFRS Caen Cedex France"},{"name":"Department of Ophthalmology Caen University Hospital Center Caen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Barjol","sequence":"additional","affiliation":[{"name":"Department of Dr Caputo Fondation A Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Mouriaux","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rennes University Hospital Center Rennes France"},{"name":"Medical School University of Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Denion","sequence":"additional","affiliation":[{"name":"Medical School Unicaen, PFRS Caen Cedex France"},{"name":"Department of Ophthalmology Caen University Hospital Center Caen Cedex France"},{"name":"Inserm, U 1075 COMETE PFRS Caen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.3.440"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2010.12.019"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80134-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1542\/peds.51.6.1032","article-title":"Systemic hypertension following ocular administration of 10 per cent phenylephrine in the neonate","volume":"51","author":"Borromeo\u2010McGrail V","year":"1973","journal-title":"Pediatrics"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3928\/0191-3913-19780301-14","article-title":"Systemic response to mydriatic eyedrops in neonates: mydriatics in neonates","volume":"15","author":"Caputo AR","year":"1978","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(73)91086-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2996"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3928\/0191-3913-19940301-18","article-title":"Additive mydriatic effect of 2.5% phenylephrine and 0.5% tropicamide eyedrops in premature babies","volume":"31","author":"Fleck BW","year":"1994","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1413"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(70)90490-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3928\/0191-3913-19850101-14","article-title":"Prolonged parasympathetic paralysis and psychosis caused by atropine eye drops","volume":"22","author":"Harel L","year":"1985","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000249700.11736.9e"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)33979-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00559.x"},{"key":"e_1_2_5_17_1","first-page":"759","article-title":"Letter: Atropine eye\u2010drops delirium","volume":"110","author":"Kounis NG","year":"1974","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00144.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2014.10.008"},{"key":"e_1_2_5_20_1","first-page":"1874","volume-title":"Complete drug reference","author":"Martindale","year":"2009"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.3.311"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2004.01.004"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2013.01.012"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2749"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12329"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.3.179"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:40:36Z","timestamp":1695541236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/aos.13175"],"URL":"https:\/\/doi.org\/10.1111\/aos.13175","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,13]]},"assertion":[{"value":"2015-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}