{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:16:17Z","timestamp":1761920177834},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess whether the early light deprivation induced by congenital cataract may influence the cone\u2010driven retinal function in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients affected by congenital cataract (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) who had undergone uncomplicated cataract extraction surgery and intraocular lens implant, and 14 healthy subjects (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) were enrolled. All patients underwent complete ophthalmological and orthoptic evaluations and best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) measurement; light\u2010adapted full\u2010field electroretinograms (<jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content>) and photopic negative responses (Ph<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>) were recorded to obtain a reliable measurement of the outer\/inner retinal function and of the retinal ganglion cells' function respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean values of light\u2010adapted <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content> a\u2010 and b\u2010wave and Ph<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content> amplitude of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> eyes were significantly reduced and photopic <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content> b\u2010wave implicit time mean values were significantly delayed when compared to <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> ones. When studying photopic <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content> mean amplitudes at 5\u00a0ms, significant differences were found when comparing <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> and control eyes. In <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> eyes, statistically significant correlations were found between a\u2010 and b\u2010 wave amplitudes and Ph<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content> amplitudes. No significant correlations were found between <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content> parameters and <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, as well as between the age of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> patients at surgery and the time elapsed from lens extraction. No significant differences were found when functional parameters of bilateral and unilateral congenital cataract (<jats:styled-content style=\"fixed-case\">uCC<\/jats:styled-content>) eyes were compared, however <jats:styled-content style=\"fixed-case\">uCC<\/jats:styled-content> eyes showed significant differences when compared with contralateral healthy eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a significant impairment of cone\u2010driven retinal responses in patients with a history of congenital cataract. These changes might result from the long\u2010lasting effects of early light deprivation on the cone retinal pathways. Our findings support the relevance of retinal involvement in deficits induced by early light deprivation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13191","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T10:32:54Z","timestamp":1471516374000},"page":"133-139","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early light deprivation effects on human cone\u2010driven retinal function"],"prefix":"10.1111","volume":"95","author":[{"given":"Paolo","family":"Esposito Veneruso","sequence":"first","affiliation":[{"name":"GI.MA Eyecare Centre Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Ziccardi","sequence":"additional","affiliation":[{"name":"\u201cG.B. Bietti\u201d Foundation \u2013 IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Magli","sequence":"additional","affiliation":[{"name":"GI.MA Eyecare Centre Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Parisi","sequence":"additional","affiliation":[{"name":"\u201cG.B. Bietti\u201d Foundation \u2013 IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Catholic University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Magli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16235"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(75)90269-2"},{"key":"e_1_2_5_4_1","first-page":"1405","article-title":"Electroretinograms and visual evoked potentials in long\u2010term monocularly deprived cats","volume":"31","author":"Baro JA","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.134.3490.1626"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.5.1878"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07037.1995"},{"key":"e_1_2_5_9_1","first-page":"635","article-title":"A proximal retinal component in the primate photopic ERG a\u2010wave","volume":"35","author":"Bush RA","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_10_1","first-page":"2205","article-title":"Photopic negative response of the human ERG: losses associated with glaucomatous damage","volume":"41","author":"Colotto A","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-6940-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1581-12.2012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.024"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(86)90019-2"},{"key":"e_1_2_5_15_1","first-page":"113","article-title":"Do horizontal cell responses contribute to the electroretinogram (ERG) in dogfish?","volume":"381","author":"Falk G","year":"1986","journal-title":"J Physiol"},{"key":"e_1_2_5_16_1","first-page":"490","article-title":"The ERG in response to alternating gratings in patients with diseases of the peripheral visual pathway","volume":"21","author":"Fiorentini A","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118032923"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.061523"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-006-9029-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90153-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.10.204"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12445"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(76)90033-X"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(95)00034-W"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-014-9477-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.007"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1523\/JNEUROSCI.19-16-06965.1999","article-title":"The critical period for ocular dominance plasticity in the Ferret's visual cortex","volume":"19","author":"Issa NP","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1133"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-1979-7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2015.1009556"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-014-9473-7"},{"key":"e_1_2_5_32_1","first-page":"111","article-title":"Behavioral and anatomical aspects of experimental amblyopia in monkeys","volume":"71","author":"von Noorden GK","year":"1973","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_33_1","first-page":"762","article-title":"Morphological and physiological changes in the monkey visual system after short\u2010term lid suture","volume":"17","author":"von Noorden GK","year":"1978","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040208014"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(92)90214-4"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.030304"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.03.008"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800002431"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1996.tb04472.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00470-6"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00389-1"},{"key":"e_1_2_5_42_1","first-page":"1124","article-title":"The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma","volume":"40","author":"Viswanathan S","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_43_1","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1523\/JNEUROSCI.21-12-04310.2001","article-title":"Unique functional properties of on and off pathways in the developing mammalian retina","volume":"21","author":"Wang GY","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4442-08.2009"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90185-1"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.978"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.1003"},{"key":"e_1_2_5_48_1","first-page":"538","article-title":"The electroretinogram of children deprived of pattern vision","volume":"13","author":"Yinon U","year":"1974","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1974.tb00386.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13191","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:40:45Z","timestamp":1695541245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,18]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/aos.13191"],"URL":"https:\/\/doi.org\/10.1111\/aos.13191","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,18]]},"assertion":[{"value":"2016-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}