{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:51:27Z","timestamp":1773971487082,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery. All eyes underwent 23\u2010gauge vitrectomy with lesion excision. One patient underwent ligation of the feeder vessel prior to lesion excision. Best\u2010corrected visual acuity and clinical course were assessed during a follow\u2010up period of at least 4\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients (mean age 27.3\u00a0years; range 19\u201332) were included, of whom two had von Hippel\u2013Lindau syndrome. Visual acuity improved in three patients (mean 4.8 lines; range 3\u201310) and remained stable at 0.0\u00a0logMAR in one patient. There were no intraoperative complications. Postoperative complications included transient mild vitreous haemorrhage (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and local epiretinal membrane formation at the excision location (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). At 4\u00a0years postoperatively, there were no long\u2010term complications. There was one case of a new lesion, which was effectively treated with laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitrectomy with RH excision seems to be an effective approach for larger RHs and could be considered an early treatment option in selected cases. Postoperative complications were limited in scope of this case series. Important points to consider during vitrectomy are effective closure of feeder and draining vessels as well as complete removal of posterior hyaloid and epiretinal membranes in order to avoid postoperative vitreous haemorrhage and proliferative vitreoretinopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13223","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T15:52:16Z","timestamp":1475164336000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Early surgical treatment of retinal hemangioblastomas"],"prefix":"10.1111","volume":"95","author":[{"given":"Koen A.","family":"van Overdam","sequence":"first","affiliation":[{"name":"The Rotterdam Eye Hospital Rotterdam The Netherlands"},{"name":"The Rotterdam Ophthalmic Institute Rotterdam The 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