{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:18:15Z","timestamp":1782181095496,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the prevalence of lipoprotein (a) [Lp(a)] and other thrombophilic disorders among retinal vein occlusion (<jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>) patients with regard to age and various risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of 100 patients with central, hemicentral or branch <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> who had undergone routine thrombophilia screening. Data were compared with 100 controls. Both cohorts were divided into three subgroups (\u226445\u00a0years, &gt;45\u2013\u226460\u00a0years or &gt;60\u00a0years), depending on the patients\u2019 age at the time of the <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> or a previous thromboembolic event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elevated Lp(a) plasma levels were significantly more prevalent among <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> patients than among controls (p\u00a0&lt;\u00a00.0001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.8). Moreover, we determined age \u226460\u00a0years by the time of the first thromboembolic event as a\u00a0strong predictor of elevated Lp(a) (p\u00a0=\u00a00.0002). The coincidence of elevated Lp(a) with other coagulation disorders further increased the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for RVO to 9.3 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201341.8). Multivariate analysis revealed the presence of cardiovascular risk factors (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.1, p\u00a0=\u00a00.0004), elevated lipoprotein (a) levels (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 5.2, p\u00a0=\u00a00.0001) and increased factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> activity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 5.9, p\u00a0=\u00a00.001) as independent risk factors for the development of <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> among patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that elevated plasma levels of Lp(a) are associated with the development of RVO. Selective screening of young patients and subjects with a personal or family history of thromboembolism may be helpful in identifying <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> patients with elevated Lp(a).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13228","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T06:36:40Z","timestamp":1471847800000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Elevated lipoprotein (a) levels are an independent risk factor for retinal vein occlusion"],"prefix":"10.1111","volume":"95","author":[{"given":"Claudia","family":"Kuhli\u2010Hattenbach","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital Goethe\u2010University Frankfurt am Main 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