{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:41:56Z","timestamp":1774899716041,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the circulation in the retinal vessels in patients with blood dyscrasia due to myeloproliferative neoplasms using non\u2010invasive retinal imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective consecutive case series of seven treatment\u2010na\u00efve patients with chronic myeloid leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), polycythemia vera (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), essential thrombocytosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) examined before and after cytoreductive treatment. We investigated retinal circulation with motion\u2010contrast imaging, retinal oximetry and spectral\u2010domain optical coherence tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retinal venous blood velocity increased by 8.14% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95<\/jats:sub> 3.67% to 12.6%, p\u00a0=\u00a00.004) and retinal arterial oxygen saturation increased by 7.23% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95<\/jats:sub> 2.9% to 11.6%, p\u00a0=\u00a00.010) at follow\u2010up (mean 12\u00a0weeks, range 5\u201314\u00a0weeks) where complete haematological remission had been achieved by cytoreductive treatment. Abnormal optical coherence tomography reflectivity patterns were present at baseline in patients with chronic myeloid leukaemia and were replaced by normal patterns at follow\u2010up. Retinopathy, in the form of cotton\u2010wool spots and retinal haemorrhages, was found at presentation in the two patients with chronic myeloid leukaemia and in one patient with polycythemia vera. The retinopathy had resolved at follow\u2010up in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With non\u2010invasive retinal imaging, we were able to demonstrate increased retinal venous blood velocity, increased retinal arterial blood oxygenation and normalization of intravascular reflectivity patterns after successful treatment of myeloproliferative neoplasms. Larger prospective studies are needed to assess the prognostic value of these non\u2010invasive imaging methods in predicting circulatory complications in myeloproliferative neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13249","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T09:14:23Z","timestamp":1475140463000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Non\u2010invasive imaging of retinal blood flow in myeloproliferative neoplasms"],"prefix":"10.1111","volume":"95","author":[{"given":"Anne","family":"Willerslev","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital and Rigshospitalet Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital and Rigshospitalet 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