{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:42:49Z","timestamp":1783741369189,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>The aim of this study was to evaluate the differences between macular inner retinal layers and peripapillary retinal nerve fibre layer (pRNFL<\/jats:styled-content>) thickness in Chinese patients with neuromyelitis spectrum optic neuritis (NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content>) and isolated optic neuritis (ION<\/jats:styled-content>) with only one episode.<\/jats:p><\/jats:sec>Methods<\/jats:title>This cross\u2010sectional study included 35 patients (35 eyes) with NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content> (NMO<\/jats:styled-content>\u2010IgG seropositive) and 46 patients (46 eyes) with ION<\/jats:styled-content> after one episode. Spectral domain optical coherence tomography (SD<\/jats:styled-content>\u2010OCT<\/jats:styled-content>) was used to quantify pRNFL<\/jats:styled-content>, macular RNFL<\/jats:styled-content> (mRNFL<\/jats:styled-content>), ganglion cell and inner plexiform layers (GCIPL<\/jats:styled-content>) and inner nuclear layer (INL<\/jats:styled-content>) thickness using an automated algorithm. Differences in OCT<\/jats:styled-content> parameters between NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content> and ION<\/jats:styled-content> were compared after adjusting for age, sex and disease duration.<\/jats:p><\/jats:sec>Results<\/jats:title>The pRNFL<\/jats:styled-content> and mRNFL<\/jats:styled-content> in some locations (average pRNFL<\/jats:styled-content>, nasal pRNFL<\/jats:styled-content>, nasal inferior (NI<\/jats:styled-content>) pRNFL<\/jats:styled-content>, nasal\/temporal (N\/T) ratio pRNFL<\/jats:styled-content>, average mRNFL<\/jats:styled-content>, inner temporal mRNFL<\/jats:styled-content>, outer nasal mRNFL<\/jats:styled-content> and outer temporal mRNFL<\/jats:styled-content>) in NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content> differed significantly from those in ION<\/jats:styled-content> (all p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). These parameters had moderate diagnostic accuracy, with area under curves (AUC<\/jats:styled-content>s) ranging from 0.684 to 0.762 for pRNFL<\/jats:styled-content> and from 0.660 to 0.700 for mRNF<\/jats:styled-content>. The thickness of GC<\/jats:styled-content>\u2010IPL<\/jats:styled-content> and INL<\/jats:styled-content> in all sectors was similar in NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content> and ION<\/jats:styled-content> (p\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.05). This study and our meta\u2010analysis of four previous studies obtained consistent results, with pooled mean difference (MD<\/jats:styled-content>) \u221210.4\u00a0\u03bc<\/jats:italic>m (95% CI<\/jats:styled-content>: \u221212.4 to \u22128.4, p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) for pRNFL<\/jats:styled-content>, \u22121.5\u00a0\u03bc<\/jats:italic>m (95% CI<\/jats:styled-content>: \u22123.5 to 0.6, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.158) for mRNFL<\/jats:styled-content> and 0.2\u00a0\u03bc<\/jats:italic>m (95% CI<\/jats:styled-content>: \u22120.4 to 0.9, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.490) for GC\u2010IPL, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Neuromyelitis spectrum optic neuritis (NMOSD\u2010ON) patients had more pRNFL<\/jats:styled-content> and mRNFL<\/jats:styled-content> loss compared to ION<\/jats:styled-content> patients after one episode. Spectral domain optical coherence tomography (SD\u2010OCT) may help to distinguish NMOSD<\/jats:styled-content>\u2010ON<\/jats:styled-content> from ION<\/jats:styled-content> with only moderate diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13257","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T09:38:40Z","timestamp":1477301920000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-4410","authenticated-orcid":false,"given":"Chunxia","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-3332","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quangang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"},{"name":"Department of Neurology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangfen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512439237"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514567216"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31829f39f1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513476562"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-41"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.066"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24351"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.09.035"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12977"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1832"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513519838"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.166207"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1982-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2015.11.3.241"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12999"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071145"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31829c510e"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099323"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7844-y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1815"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9324"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345042.53843.d5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1344-7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.727"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515578888"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12215"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.108"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af78b8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15314"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/WNO.0000000000000204","article-title":"Ganglion cell layer analysis unmasks axonal loss in anterior optic neuritis","volume":"35","author":"Rebolleda G","year":"2015","journal-title":"J Neuroophthalmol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12658"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514538110"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066151"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.920"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034823"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70259-X"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13257","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:53:15Z","timestamp":1695567195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/aos.13257"],"URL":"https:\/\/doi.org\/10.1111\/aos.13257","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]},"assertion":[{"value":"2016-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}