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All patients in the trial were followed up regularly by standard automated perimetry and monoscopic optic disc photography, and the median follow\u2010up time was 8\u00a0years. Progression was assessed in series of optic disc photographs and in series of visual fields using glaucoma change probability maps and the predefined <jats:styled-content style=\"fixed-case\">EMGT<\/jats:styled-content> progression criterion. The proportion of progressions detected first in visual fields and the proportion detected first in optic disc photographs were compared at different stages of glaucoma severity defined by the perimetric mean deviation (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) of the baseline visual field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assessment of 210 eyes with early visual field loss, 83 eyes with moderate field loss, and 13 eyes with advanced field loss showed that, among the eyes exhibiting progression, the progression was detected first in the visual field in 80%, 79% and 100%, respectively. The predominance of visual field progressions at all stages was still apparent when using narrower (3\u2010<jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> intervals for staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">EMGT<\/jats:styled-content> material on eyes with manifest open\u2010angle glaucoma, the initial progression was detected much more often in the visual field series than in the optic disc photographs at all stages of disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13290","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T06:07:06Z","timestamp":1477375626000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Detection of glaucoma progression by perimetry and optic disc photography at different stages of the disease: results from the Early Manifest Glaucoma Trial"],"prefix":"10.1111","volume":"95","author":[{"given":"HannaMaria","family":"\u00d6hnell","sequence":"first","affiliation":[{"name":"Department of ophthalmology Lund University, Skane University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Heijl","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Faculty of Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cancer Epidemiology Faculty of Medicine Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boel","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Faculty of Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.01.014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2005.06.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.10.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.04.015"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14994"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1997.tb00121.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90018-V"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.01.024"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1492"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.04.031"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02577.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177013815"},{"key":"e_1_2_5_14_1","first-page":"135","volume-title":"Glaucoma diagnosis. 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