{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:35:52Z","timestamp":1793399752415,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vaern om Synet"},{"name":"Synoptik Fonden"},{"name":"Svend Helge Arvid Schr\u00f8der og Hustru Ketty Lydia Larsen Schr\u00f8ders Fond"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Optic disc drusen (<jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>) is hyaline deposits in the optic nerve head seen in 1\u20132% of the population. Long\u2010term evolution of <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> anatomy and visual field defects in <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> patients is a key factor for learning more about pathophysiology and prognosis of the condition. With a median follow\u2010up period of 56\u00a0years, this is the first study that evaluates superficial optic disc anatomy and visual fields in patients with <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> over a life span.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational case series investigating progression of superficial optic disc anatomy and visual fields in <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> patients. Eight patients with hereditary <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age at initial and follow\u2010up examination was, respectively, 16.8 and 73.3\u00a0years. The median follow\u2010up time was 56\u00a0years. A minimal or non\u2010existing change in superficial <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> anatomy (size and number) was seen in 10 of 12 eyes. There was a tendency towards more anatomical change in subjects younger at first examination. A 27% decrease in Goldmann perimetric visual field area (cm<jats:sup>2<\/jats:sup>) was found between initial and follow\u2010up examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Minimal or no change in superficial optic disc anatomy and visual fields in <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> patients oldest at the initial examination suggests that anatomical progression of <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> in patients with hereditary <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> happens primarily before adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13315","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T10:55:28Z","timestamp":1482231328000},"page":"352-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010term evolution of superficial optic disc drusen"],"prefix":"10.1111","volume":"95","author":[{"given":"Lasse","family":"Malmqvist","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet University of Copenhagen Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Lund\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet University of Copenhagen Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet University of Copenhagen Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12314"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492006000500003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/74.1.95"},{"key":"e_1_2_6_5_1","first-page":"3","article-title":"Optic disc drusen in children","volume":"129","author":"Erkkila H","year":"1977","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000303448"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00986.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3928\/0191-3913-19880701-09","article-title":"Optic disc drusen in children","volume":"25","author":"Hoover DL","year":"1988","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00136734"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1957.00940010127011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.01.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.01.024"},{"key":"e_1_2_6_13_1","first-page":"91","article-title":"Drusen of the optic disk. 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