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However, regression of treatment and iatrogenic keratectasia remain to be a major concern, especially in treating thin cornea with high ametropia. Collagen cross\u2010linking (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) is an effective method in stopping keratoconus progression through increasing the biomechanical strength of the cornea. Adjuvant cross\u2010linking to refractive procedures can theoretically help prevent regression and reduce the risk of keratectasia development by increasing the mechanical stability of cornea. During the procedure, riboflavin is directly applied to the corneal stroma, thereby reducing the need of de\u2010epithelialization as in the conventional protocol for keratoconus. Currently, there is still no consensus regarding the indication of <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> during refractive procedure, nor any standardized treatment protocol. This article aims to summarize the current evidence regarding the use of adjuvant <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LASIK<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13324","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T06:17:28Z","timestamp":1480659448000},"page":"660-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Combined application of prophylactic corneal cross\u2010linking and laser <i>in\u2010situ<\/i> keratomileusis \u2013 a review of literature"],"prefix":"10.1111","volume":"95","author":[{"given":"Tommy C. 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