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Patients with neovascular <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> were grouped based on time of blood sampling in relation to diagnosis of neovascular <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>: diagnosis of new neovascular <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> more than 30\u00a0days before blood sampling, within 30\u00a0days of blood sampling and more than 30\u00a0days after blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 347 recruited participants, 330 fulfilled the eligibility criteria (77 age\u2010matched controls, 33 with early <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>, 56 with geographic atrophy and 164 with neovascular <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>). We did not find any differences in the differential counts between patients at different stages of <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> and age\u2010matched control individuals. However, lymphocyte and monocytes\u2013basophils\u2013eosinophils mixed (<jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content>) counts were both significantly increased in patients with new neovascular <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>. Among these patients; higher <jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content> correlated with lower <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, larger central foveal thickness and larger total lesion size; higher lymphocytes correlated with smaller total lesion size; higher neutrophils correlated with <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> lesion size; and higher neutrophil\u2010to\u2010lymphocyte ratio correlated with larger lesion size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic leucocyte activity is associated with onset of <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> and correlate with lesion size and <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, which suggest that acute systemic immune activity may play a role in neovascular 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