{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:35:45Z","timestamp":1789572945238,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Intra\u2010arterial chemotherapy (\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      ) has become an essential technique for the treatment of advanced and relapsed intra\u2010ocular retinoblastoma. The outcome of\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      for retinoblastoma is influenced by a variety of medical and non\u2010medical factors. In this study, we aimed to examine the outcome of\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      and determine the factors influencing clinical outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 107 eyes of 73 patients with retinoblastoma undergoing\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      between January 2011 and April 2013 were retrospectively reviewed for clinical outcomes. The factors influencing clinical outcomes were determined using univariate and multivariate analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      , an overall globe salvage rate of 78.5% was observed during follow\u2010up periods. Specifically, globe salvage was achieved in Group B (100%), Group C (100%), Group D (78.6%), and Group E (62%). Short\u2010term ocular adverse events included eyelid oedema (14%), bulbar conjunctiva congestion (29.9%) and excessive tearing (9.3%). Long\u2010term complications included vitreous haemorrhage (8.4%), subretinal haemorrhage (9.3%), retinal vasculopathy (7.5%) and ophthalmic artery spasm with reperfusion (4.7%). Univariate and multivariate analyses showed that the globe salvage of\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      was significantly associated with tumour staging and previous treatment (p\n                      <jats:italic>\u00a0&lt;\u00a0<\/jats:italic>\n                      0.05, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Intra\u2010arterial chemotherapy (IAC) is safe and effective for the management of retinoblastoma. Patients with advanced retinoblastoma and previous failed treatment may have a poor outcome after\n                      <jats:styled-content style=\"fixed-case\">IAC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13333","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T08:22:46Z","timestamp":1479802966000},"page":"613-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Outcome of intra\u2010arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study"],"prefix":"10.1111","volume":"95","author":[{"given":"Miaojuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou 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