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Patients received a single dose of either unpreserved trehalose 3%\u00a0+\u00a0hyaluronic acid 0.15% (<jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content>), hyaluronic acid 0.2% (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) or polyethylene glycol 0.4%\u00a0+\u00a0propylene glycol 0.3% (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) eye drops. In total, 60 patients were included and <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> was measured using a custom\u2010built <jats:styled-content style=\"fixed-case\">UHR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> at baseline was 3.5\u00a0\u00b1\u00a00.7\u00a0<jats:italic>\u03bc<\/jats:italic>m. There was a significant difference in the time\u2013course of <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> between the three groups (p\u00a0=\u00a00.001 between groups). Ten minutes after instillation, <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> increased by 155.8\u00a0\u00b1\u00a086.6%, 65.7\u00a0\u00b1\u00a071.5% and 33.4\u00a0\u00b1\u00a019.6% in the <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> group, respectively (p\u00a0&lt;\u00a00.001 between groups). Thirty minutes after instillation, the effect of all three different agents on <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> was comparable. Sixty and 120\u00a0min after administration, a significant increase in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> was only seen for the <jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content> group, but not for the other products (60\u00a0min: p\u00a0&lt;\u00a00.021 between groups; 120\u00a0min: p\u00a0&lt;\u00a00.037 between groups).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, we observed differences in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> after administration of the lubricant gels. Ten minutes after instillation, a pronounced increase in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> was observed in all groups. As compared to the other products, the combination of trehalose 3%\u00a0+\u00a0hyaluronic acid 0.15% offers a significantly longer increase in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> indicating for a longer residence time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13342","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T09:16:47Z","timestamp":1482052607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh\u2010resolution optical coherence tomography"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-0438","authenticated-orcid":false,"given":"Piotr A.","family":"Wozniak","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"},{"name":"Department of 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