{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:04:53Z","timestamp":1754262293230},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Selective laser trabeculoplasty (<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>) is known to reduce intraocular pressure (IOP) effectively. The aim of this study, however, was to evaluate the effect of<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>on ocular haemodynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 69 eyes of 69 patients (age 67.8\u00a0\u00b1\u00a09.9\u00a0years) with already treated primary open\u2010angle glaucoma who were assigned for<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>for further<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>reduction were consecutively enrolled in this prospective interventional case series. Intraocular pressure, the ocular pulse amplitude (<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>), ocular pulse volume (<jats:styled-content style=\"fixed-case\">OPV<\/jats:styled-content>) and pulsatile ocular blood flow (<jats:styled-content style=\"fixed-case\">pOBF<\/jats:styled-content>) were assessed with the Ocular Blood Flow Analyzer prior to and 3\u00a0months after<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intraocular pressure was statistically significantly reduced from 16.0\u00a0\u00b1\u00a05.4\u00a0mmHg to 12.8\u00a0\u00b1\u00a04.0\u00a0mmHg (p\u00a0=\u00a00.001). The<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>did not change (p\u00a0=\u00a00.783) after<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>reduction following<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">OPV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">pOBF<\/jats:styled-content>increased statistically significantly.<jats:styled-content style=\"fixed-case\">OPV<\/jats:styled-content>increased from 7.33\u00a0\u00b1\u00a03.05 to 8.59\u00a0\u00b1\u00a03.35\u00a0\u03bcl (17.2%; p\u00a0=\u00a00.001) and<jats:styled-content style=\"fixed-case\">pOBF<\/jats:styled-content>from 17.11\u00a0\u00b1\u00a05.42 to 19.74\u00a0\u00b1\u00a06.59\u00a0\u03bcl\/s (15.4%; p\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Selective laser trabeculoplasty probably does not induce any pharmacological changes effecting systemic blood pressure or ocular blood flow as topical<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering medication might do, nor does it change biomechanical properties of the eye as surgery could. Therefore, an increase in ocular blood flow following<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>can only be explained by the reduction in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>and might be a sign of dysfunctional autoregulation in glaucoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13360","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T05:33:27Z","timestamp":1485840807000},"page":"374-377","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of selective laser trabeculoplasty on ocular haemodynamics in primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"95","author":[{"given":"Karin R.","family":"Pillunat","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Spoerl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naim","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz E.","family":"Pillunat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"198","volume-title":"Adler's Physiology of the Eye","author":"Alm A","year":"1992"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00046-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2522-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199506000-00013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00223-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790601.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(83)90017-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0461"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199712000-00012"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12354"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.8.1104"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02141.x"},{"key":"e_1_2_5_16_1","first-page":"2754","article-title":"Calculation of the pulsatile ocular blood flow","volume":"33","author":"Krakau CE","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_17_1","first-page":"93","volume-title":"Ocular blood flow in glaucoma","author":"Lambrou GN","year":"1989"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(78)90049-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1755-3768.1989.tb07080.x","article-title":"Blood flow in the human eye","volume":"191","author":"Langham ME","year":"1989","journal-title":"Acta Ophthalmol Suppl"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200604000-00009"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(94)90065-5"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73763-8"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688109019968"},{"key":"e_1_2_5_24_1","first-page":"1105","article-title":"Migraine and low\u2010tension glaucoma. 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