{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:09:18Z","timestamp":1768277358751,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine longer\u2010term postsurgical safety and efficacy of a new expander for Schlemm's canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a non\u2010comparative, prospective study, 42 White patients with medically uncontrolled primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>) underwent primary canaloplasty with &gt;2\u2010year follow\u2010up. The bleb\u2010independent procedure comprised catheter\u2010assisted canaloplasty and implantation of two Stegmann Canal Expanders to maintain trabecular distension and canal patency over 180\u00b0. Intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>), glaucoma medication use and complications were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was 26.8\u00a0\u00b1\u00a05.6\u00a0mmHg presurgery, 12.8\u00a0\u00b1\u00a01.5\u00a0mmHg at 6\u00a0months, 13.2\u00a0\u00b1\u00a01.2\u00a0mmHg at 12\u00a0months and 13.3\u00a0\u00b1\u00a02.5\u00a0mmHg at 24\u00a0months (p\u00a0&lt;\u00a00.001). Rate of complete success, defined as <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> \u226421, \u226418 and \u226416\u00a0mmHg and a\u00a0\u2265\u00a030% <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction, was 85% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.76\u20130.95), 85% (0.76\u20130.95) and 82% (0.70\u20130.96) at 12\u00a0months and 83% (0.73\u20130.94), 80% (0.70\u20130.92) and 80% (0.70\u20130.92) at 24\u00a0months. Preoperative factors were not significant predictors of \u226416\u00a0mmHg <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction: <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>]: 0.68; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.44\u20131.04; p\u00a0=\u00a00.08), mean visual defect (1.06; 0.90\u20131.20; p\u00a0=\u00a00.47), number of medications (0.59; 0.17\u20132.14; p\u00a0=\u00a00.42) and age (0.96; 0.87\u20131.13; p\u00a0=\u00a00.41). Number of medications dropped from 2.8\u00a0\u00b1\u00a00.4 presurgery to 0.2\u00a0\u00b1\u00a00.5 postsurgery (p\u00a0&lt;\u00a00.001). Mean preoperative best\u2010corrected visual acuity was 0.19\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 0.21 (range: 0\u20131.6), and log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> was similar to 0.23\u00a0\u00b1\u00a00.16 (range: 0\u20131.6; p\u00a0=\u00a00.42) after a mean follow\u2010up of 27.4\u00a0months. Complications included peripheral Descemet's membrane detachment (7.2%) and trimming of the expander (4.7%) during surgery, and transient microhyphaema (23.8%) and <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> elevation (7.2%) postsurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Canaloplasty with the Stegmann Canal Expander was a safe and effective procedure to reduce <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> in White patients with moderate to advanced <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13372","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:38:05Z","timestamp":1484321885000},"page":"503-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Canaloplasty with Stegmann Canal Expander for primary open\u2010angle glaucoma: two\u2010year clinical results"],"prefix":"10.1111","volume":"95","author":[{"given":"Matthias C.","family":"Grieshaber","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sefako Makgatho Health Sciences University (former Medical University of Southern Africa); Medunsa Pretoria South Africa"},{"name":"Department of Ophthalmology University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schoetzau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Basel Basel Switzerland"},{"name":"Center for Biomedical Statistics University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans R.","family":"Grieshaber","sequence":"additional","affiliation":[{"name":"Grieshaber Ophthalmic Research Foundation Schaffhausen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stegmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sefako Makgatho Health Sciences University (former Medical University of Southern Africa); Medunsa Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01028-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705915"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/457605"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000103"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1728-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12917"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ITO.0b013e3182328a45"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.163170"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181e3d46e"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02293.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12513"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305540"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000397"},{"key":"e_1_2_5_15_1","volume-title":"Consensus on Definition of Success","author":"Heuer DK","year":"2009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31814b98f7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13026"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.03.051"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.01.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.10.055"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12722"},{"key":"e_1_2_5_22_1","first-page":"189","article-title":"Minimally invasive glaucoma surgery: current status and future prospects","volume":"10","author":"Richter GM","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.4.441"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2014.09.002"},{"key":"e_1_2_5_25_1","first-page":"229","article-title":"Visco\u2010canalostomy: a new surgical technique for open angle glaucoma","volume":"25","author":"Stegmann R","year":"1995","journal-title":"An Inst Barraquer"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00972-2"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210501500204"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:10:42Z","timestamp":1695535842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/aos.13372"],"URL":"https:\/\/doi.org\/10.1111\/aos.13372","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]},"assertion":[{"value":"2016-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}