{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:46:58Z","timestamp":1780472818193,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe clinical features, risk factors and complications in a cohort of Swedish children with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) screened for uveitis between 2002 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 299 children with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> (93 male, 206 female; median age 5.0\u00a0years at diagnosis) were retrospectively scrutinized focusing on subtype of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, onset of arthritis\/uveitis, presence of antinuclear antibodies (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>) and ophthalmological status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Uveitis was found in 32 (11%) children, 78% bilaterally affected. The median age of arthritis onset in children who developed uveitis was 2.5\u00a0years (range 1\u201310) versus 5.0\u00a0years (range 1\u201315) in those who did not. Sex ratio was 3.5:1 (girl:boy). The most prevalent <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> subtype was oligoarthritis (75%). All but one child with uveitis was found to be <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> (+). The median interval between diagnosis of arthritis and uveitis was 12\u00a0months. Only one child developed uveitis between the fourth and fifth years after arthritis onset. Ocular complications were recorded in 45.6% (26\/57 affected eyes) at last follow\u2010up. On univariate analysis, both young age at arthritis onset and <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> positivity were possible predictors for developing uveitis, but on multivariate analysis, the latter was the most important predictor (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 16.25, 95%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.19\u2013120.44; p\u00a0=\u00a00.006, Cox regression analysis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Almost all of the children developing <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\u2010associated uveitis did so within 4\u00a0years after arthritis onset, a fact that accentuates the importance of early initiation of ophthalmological screening and more frequent regular follow\u2010ups during the first 4\u00a0years. The most important predictor for developing uveitis was <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> positivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13388","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T03:22:44Z","timestamp":1487215364000},"page":"741-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"95","author":[{"given":"Maria","family":"Papadopoulou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Oskarsdottir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Andersson Gr\u00f6nlund","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0018-8"},{"key":"e_1_2_5_3_1","first-page":"343","article-title":"Juvenile idiopathic arthritis\u2010associated uveitis: data from a region in western Greece","volume":"4","author":"Asproudis I","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_4_1","unstructured":"British Society for Paediatric and Adolescent Rheumatology(2006):Guidelines for Screening for Uveitis in Juvenile Idiopathic Arthritis (JIA). 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