{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:16:27Z","timestamp":1762899387671},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the role of small cystic macular changes as a prognostic factor for the recurrence of macular oedema (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>) in patients with branch retinal vein occlusion (<jats:styled-content style=\"fixed-case\">BRVO<\/jats:styled-content>) treated with anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed retrospective chart analysis of 116 patients treated with intravitreal injection of ranibizumab (<jats:styled-content style=\"fixed-case\">IVR<\/jats:styled-content>) or bevacizumab (<jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> secondary to <jats:styled-content style=\"fixed-case\">BRVO<\/jats:styled-content>. At the baseline and monthly follow\u2010up visits over a period of 12\u00a0months, a comprehensive ophthalmologic examination including best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) and volume scan of macula using Spectral domain optical coherence tomography (SD\u2010OCT) were performed. Patients without <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> &lt;250\u00a0<jats:italic>\u03bc<\/jats:italic>m) were screened for the presence of intraretinal cysts. In these patients, the changes in <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> were evaluated over a period of 12\u00a0months and compared with the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">IVR<\/jats:styled-content> group (41 patients), 91 events of macular cysts, without a worsening of <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, were detected by <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. In 89 of 91 events (97%), <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> deteriorated significantly (p\u00a0&lt;\u00a00.0001) within the next 4\u201311 (in mean 7.1\u00a0\u00b1\u00a02.0) weeks. <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> decreased from 0.38\u00a0\u00b1\u00a00.25 to 0.49\u00a0\u00b1\u00a00.27 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> increased significantly from 223\u00a0\u00b1\u00a043 to 605\u00a0\u00b1\u00a0244\u00a0<jats:italic>\u03bc<\/jats:italic>m. In the <jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content> group (19 patients), 54 events of cystic changes were detected. All of these patients showed significant worsening of <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> from 0.40\u00a0\u00b1\u00a00.19 to 0.57\u00a0\u00b1\u00a00.22 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> from 251\u00a0\u00b1\u00a017 to 490\u00a0\u00b1\u00a0147\u00a0<jats:italic>\u03bc<\/jats:italic>m within 4\u201310 (in mean 7.8\u00a0\u00b1\u00a02.8) weeks after the first presence of small macular cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">BRVO<\/jats:styled-content> patients treated with anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> drugs, the macular cystic changes may be used as an early indicator for impending recurrence of <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>, with the decrease in <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> in the following weeks. These patients should be scheduled for a next visit within 6\u20138\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13396","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T07:36:40Z","timestamp":1488872200000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Macular cystic changes as predictive factor for the recurrence of macular oedema in branch retinal vein occlusion"],"prefix":"10.1111","volume":"95","author":[{"given":"Eric","family":"Tilgner","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiara","family":"Dalcegio Favretto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology S\u00e3o Jos\u00e9 Hospital \u2013 Dr Homero de Miranda Gomes Hospital Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tuisl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matus","family":"Rehak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12815"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.021"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.08.031"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1545746"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.885533"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S76261"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858231"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02292.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.92"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12488"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2332"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12772"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20140404-01"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303121"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:04:31Z","timestamp":1695477871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/aos.13396"],"URL":"https:\/\/doi.org\/10.1111\/aos.13396","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]},"assertion":[{"value":"2015-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}