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Beyond their structural, functional and neuroprotective roles, omega\u20103 PUFA<\/jats:styled-content>s may favour the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD<\/jats:styled-content>). We examined the associations of MPOD<\/jats:styled-content> with plasma omega\u20103 PUFA<\/jats:styled-content>s in subjects with family history of AMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The Limpia study is a double\u2010blind, placebo\u2010controlled, prospective randomized clinical trial performed in 120 subjects. Subjects with at least one parent treated for neovascular AMD<\/jats:styled-content>, aged 40\u201370, with a best corrected visual acuity (BCVA) >20\/25, free of late AMD<\/jats:styled-content> and other major eye conditions and with no use of supplement containing lutein or zeaxanthin the preceding year were recruited in Bordeaux and Dijon, France. At baseline, MPOD<\/jats:styled-content> within 1\u00b0 of eccentricity was measured by modified Heidelberg retinal analyser (Heidelberg, Germany) and plasma omega\u20103 PUFA<\/jats:styled-content>s by gas chromatography. Medical history and lifestyle data were collected from a standardized questionnaire. Associations of MPOD<\/jats:styled-content> with plasma omega\u20103 PUFA<\/jats:styled-content>s were assessed at the baseline examination, using mixed linear models adjusted for age, gender, centre, body mass index, smoking, plasma high\u2010density lipoprotein (HDL) cholesterol and lutein+zeaxanthin.<\/jats:p><\/jats:sec>Results<\/jats:title>After multivariate adjustment, high MPOD<\/jats:styled-content> was significantly associated with higher level of plasma docosapentaenoic acid (DPA<\/jats:styled-content>) (\u03b2\u00a0=\u00a00.029, 95% CI<\/jats:styled-content>: 0.003, 0.055; p\u00a0=\u00a00.03). Plasma alpha linolenic, eicosapentaenoic and docosahexaenoic acids were not significantly associated with MPOD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In the Limpia study, high MPOD<\/jats:styled-content> within 1\u00b0 was significantly associated with higher plasma levels of omega\u20103 DPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13408","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T05:56:41Z","timestamp":1488952601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Plasma long\u2010chain omega\u20103 polyunsaturated fatty acids and macular pigment in subjects with family history of age\u2010related macular degeneration: the Limpia Study"],"prefix":"10.1111","volume":"95","author":[{"given":"B\u00e9n\u00e9dicte M. 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