{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:02:17Z","timestamp":1787065337386,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the efficacy of combination povidone\u2010iodine (PVP\u2010I) 1.0% eyedrops and dexamethasone 0.1% eyedrops in the treatment of adenoviral keratoconjunctivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In a prospective, randomized, controlled, double\u2010blinded clinical trial patients with recent adenoviral keratoconjunctivitis (diagnosed clinically and confirmed by\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      ), we randomly divided into three treatment groups: study group \u2013 received PVP\u2010I 1.0% and dexamethasone 0.1%, control 1 group \u2013 received dexamethasone 0.1% and control 2 group \u2013 received lubricating eyedrops (hypromellose 0.3%). The treatment was administered four times a day in each group. All patients were examined and filled a questionnaire before treatment and on the 3rd, 5th and 7th days of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included in the study 78 eyes (26 in each group). Adenovirus type 8 was the most common pathogen (83% of cases). The fastest improvement in patients red eyes, discharge, superficial punctate keratitis and pseudomembranes was observed in the study group (p\u00a0&lt;\u00a00.001). Those patients reached a near complete recovery in 5\u20137\u00a0days, which was also confirmed by reduction in Adenovirus titres by\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      . The slowest improvement was in the control 2 group. Subepithelial infiltrates (SEI) were observed in 44% of the control 1 group, 20% of the control 2 group and in 0% of the study group. The rate of reduction in Adenovirus titres was the slowest in the control 1 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of PVP\u2010I 1.0% and dexamethasone 0.1% four times a day can reduce symptoms and expedite recovery in epidemic keratoconjunctivitis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13416","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T05:43:24Z","timestamp":1490420604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Treatment of adenoviral keratoconjunctivitis with a combination of povidone\u2010iodine 1.0% and dexamethasone 0.1% drops: a clinical prospective controlled randomized 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