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In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre\u2010 and\/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections. A key distinguishing feature of intravitreal injections from most other invasive procedures is the fact that they are often repeated on multiple occasions to the same eye. Given the lack of evidence to support topical antibiotics as an effective method of prophylaxis for postinjection endophthalmitis, it appears that more widespread education of ophthalmologists is required to avoid continued inappropriate use. Revision of drug labels in some jurisdictions, and amendment of local\/professional society guidelines, may be required to assist in achieving this goal. Emphasis should be placed on antisepsis and aseptic technique, which are the major proven methods of endophthalmitis prevention, rather than antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13417","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T09:49:13Z","timestamp":1493113753000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Topical antibiotics and intravitreal injections"],"prefix":"10.1111","volume":"96","author":[{"given":"Alex P.","family":"Hunyor","sequence":"first","affiliation":[{"name":"University of Sydney Sydney New South Wales Australia"},{"name":"Sydney Eye Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Merani","sequence":"additional","affiliation":[{"name":"Sydney and Macquarie Universities Sydney New South Wales Australia"},{"name":"Concord Repatriation General Hospital Concord New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archie","family":"Darbar","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital St Leonards New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Korobelnik","sequence":"additional","affiliation":[{"name":"Service d'ophtalmologie CHU de Bordeaux Bordeaux France"},{"name":"Univ. 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