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It is now well recognized that the pathophysiology of chronic\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      can include a cycle of inflammation involving both innate and adaptive immune responses. Recently,\n                      <jats:italic>in\u00a0vitro\/in\u00a0vivo<\/jats:italic>\n                      models have been used to obtain a better understanding of\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      \u2010related inflammatory processes at molecular\/cellular levels although they do not truly reproduce the complex and chronic hallmarks of human\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      . In clinical\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      research, advanced techniques such as impression cytology, conjunctival biopsy,\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      confocal microscopy and multiplex tear analyses have allowed an improved assessment of inflammation in\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      patients. This was supported by the identification of reliable inflammatory markers including matrix metalloproteinase\u20109, human leucocyte antigen\u2010\n                      <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                      or intercellular adhesion molecule\u20101 in tears and impression cytology samples. One of the current therapeutic strategies focuses on breaking the inflammatory cycle perpetuating the ocular surface disease, and preclinical\/clinical research has led to the development of promising anti\u2010inflammatory compounds. For instance, cyclosporine, already approved in the United States, has recently been authorized in Europe to treat\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      associated with severe keratitis. In addition, other agents such as corticosteroids, doxycycline and essential fatty acids, through their anti\u2010inflammatory properties, show encouraging results. We now have a clearer understanding of the inflammatory processes involved in\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      , and there is hope that the still emerging preclinical\/clinical findings will be translated into new and highly effective therapies for patients in the near future.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13436","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T03:58:59Z","timestamp":1491623939000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Clinical impact of inflammation in dry eye disease: proceedings of the\n                    <scp>ODISSEY<\/scp>\n                    group meeting"],"prefix":"10.1111","volume":"96","author":[{"given":"Christophe","family":"Baudouin","sequence":"first","affiliation":[{"name":"Centre 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