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This study evaluated a novel device for subtenon drug delivery to the vitreous, relative to a single subconjunctival injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty adult New Zealand White rabbits were randomly assigned to receive demethylvancomycin (<jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>) by continuous subtenon delivery with the flow rate of 0.1\u00a0ml\/hr for 24\u00a0hr, or as a single 0.3\u00a0ml subconjunctival injection in the right eyes. Rabbits were killed in subgroups of six at 1, 3, 6, 12 and 24\u00a0hr. The <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> concentration of the vitreous humour of the right eye was analysed by high\u2010performance liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the vitreous <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> concentration of the subtenon group was significantly higher than that of the subconjunctival group (<jats:italic>F<\/jats:italic>\u00a0=\u00a025.928, p\u00a0=<jats:italic>\u00a0<\/jats:italic>0.001). The <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> concentration of the subtenon group was also significantly higher than that of the subconjunctival group at 3, 6, 12 and 24\u00a0hr (<jats:italic>t\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2.457, 5.064, 3.085, 4.207; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04, 0.01, 0.018, 0.004, respectively). In the subtenon group, the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> concentration reached maximum (2.41\u00a0\u00b1\u00a00.67\u00a0<jats:italic>\u03bc<\/jats:italic>g\/ml) at 6\u00a0hr, and at 24\u00a0hr was 2.37\u00a0\u00b1\u00a01.23\u00a0<jats:italic>\u03bc<\/jats:italic>g\/ml. In the subconjunctival group, the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> concentration reached maximum (0.48\u00a0\u00b1\u00a00.27\u00a0<jats:italic>\u03bc<\/jats:italic>g\/ml) at 1\u00a0hr and declined to 0.09\u00a0\u00b1\u00a00.05\u00a0<jats:italic>\u03bc<\/jats:italic>g\/ml at 24\u00a0hr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subtenon application with this novel minimally invasive design is an effective method for delivering an appropriate drug to the vitreous in a sustained and controllable amount.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13448","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T06:22:40Z","timestamp":1491718960000},"page":"595-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preliminary study of a controllable device for subtenon drug infusion in a rabbit 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