{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T20:27:32Z","timestamp":1749328052262},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare subconjunctival scarring after vitrectomy in rabbit eyes using different gauge systems by analysing anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) images and histological sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vitrectomy using 20\u2010, 23\u2010, 25\u2010 and 27\u2010gauge systems was performed for rabbits. Anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) images of the incision sites were obtained before and at day 1, 7 and 1\u00a0month after surgery. We measured the thickness of conjunctival epithelium, stroma, Tenon's capsule and total conjunctiva of these three layers, then determined the preservation rates of the borderlines between each layer. Surgical invasion was estimated by histological observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The thickness of total conjunctiva, or the thickness of both conjunctival stroma and Tenon's capsule in the 20\u2010gauge group was significantly thicker than that in the 27\u2010gauge group at day 1 and day 7 after surgery. Preservation rates of the conjunctival stroma\/Tenon's capsule borderline were significantly lower in the 20\u2010gauge group than in the 25\u2010 and 27\u2010gauge groups at day 1, day 7 and 1\u00a0month. Preservation rates of the Tenon's capsule\/sclera borderline were significantly lower in the 20\u2010gauge group than in the 25\u2010 and 27\u2010gauge groups at 1\u00a0month. In the 27\u2010gauge group, the number of <jats:italic>\u03b1<\/jats:italic>\u2010smooth muscle actin\u2010positive fibroblasts was significantly smaller than in the 20\u2010gauge group at day 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the finding of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> and histology, micro incision vitreous surgery, especially using 27\u2010gauge, contributed to less subconjunctival scarring postoperatively. Therefore, the 27\u2010gauge pars plana vitrectomy (PPV) may be a more effective technique for preserving the structure of conjunctiva.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13459","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T07:08:59Z","timestamp":1497856139000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of subconjunctival scarring after microincision vitrectomy surgery using 20\u2010, 23\u2010, 25\u2010 and 27\u2010gauge systems in rabbits"],"prefix":"10.1111","volume":"95","author":[{"given":"Makoto","family":"Gozawa","sequence":"first","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Takamura","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Miyake","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Arimura","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Takihara","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Inatani","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Department of Ophthalmology University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181ab98ae"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13121"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050240109050"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152606"},{"key":"e_1_2_6_6_1","first-page":"252","article-title":"Evidence for the nonmuscle nature of the \u2018myofibroblast\u2019 of granulation tissue and hypertropic scar. 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