{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:49:27Z","timestamp":1779900567560,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the impact of sequential and combined surgery [cataract surgery and 23\u2010gauge pars plana vitrectomy (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) with peeling] on corneal endothelium cell density (CED) and corneal biomechanical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phakic eyes with epiretinal membrane (ERM) were prospectively allocated to (i) cataract surgery and subsequent <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> group), (ii) <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and subsequent cataract surgery (<jats:styled-content style=\"fixed-case\">VIT<\/jats:styled-content> group) or (iii) phacovitrectomy (<jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content> group). Eyes were examined at baseline, 1\u00a0month after each surgery, and at 3 and 12\u00a0months follow\u2010up. Corneal endothelium cell density (CED) was assessed with non\u2010contact specular microscopy. Pachymetry [central cornea thickness (<jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content>)], keratometry and cornea volume (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) were measured with Pentacam Scheimpflug camera. Primary outcome was change in <jats:styled-content style=\"fixed-case\">CED<\/jats:styled-content> after 12\u00a0months; secondary outcomes were changes in <jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> after 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two eyes were enrolled and allocated to the three groups. The mean preoperative <jats:styled-content style=\"fixed-case\">CED<\/jats:styled-content> was 2776, 2794 and 2653 cells\/mm<jats:sup>2,<\/jats:sup> which decreased significantly at 12\u00a0months by 15.3, 20.0 and 19.3% in the <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VIT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content> group. There was no significant difference in percentage cell loss between the groups at final follow\u2010up. The <jats:styled-content style=\"fixed-case\">CED<\/jats:styled-content> decreased significantly after cataract surgery, but was unaffected by <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>. Central cornea thickness (CCT) increased by 10\u00a0<jats:italic>\u03bc<\/jats:italic>m (p\u00a0=\u00a00.005) and <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> by 1.38\u00a0mm<jats:sup>3<\/jats:sup> (2.3%, p\u00a0&lt;\u00a00.001) in the <jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content> group. There were no significant differences in <jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> between the groups at final follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined and sequential surgery in <jats:styled-content style=\"fixed-case\">ERM<\/jats:styled-content> leads to a small decrease in <jats:styled-content style=\"fixed-case\">CED<\/jats:styled-content>. Performing cataract surgery before, after or in combination with vitrectomy did not make any significant difference with respect to final <jats:styled-content style=\"fixed-case\">CED<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CCT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13474","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T12:02:42Z","timestamp":1494244962000},"page":"493-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Corneal endothelial cell loss and corneal biomechanical characteristics after two\u2010step sequential or combined phaco\u2010vitrectomy surgery for idiopathic epiretinal membrane"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-6504","authenticated-orcid":false,"given":"Hassan","family":"Hamoudi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Copenhagen University Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik Correll","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Copenhagen University Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"La Cour","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Copenhagen University Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01281.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S75580"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(83)90068-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199901000-00012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.07.015"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050100054017"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.21.4.788.5548"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200003000-00006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34166-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80173-3"},{"issue":"2","key":"e_1_2_5_12_1","first-page":"291","article-title":"Endothelial cell loss after cataract surgery\u2013the problem of interpretation","volume":"102","author":"Jacobs PM","year":"1982","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307301"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.080"},{"key":"e_1_2_5_15_1","unstructured":"Ministry(2014):The Danish Code of Conduct for Research Integrity. 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