{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:14:59Z","timestamp":1790352899268,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study sought to determine whether isolated third, fourth and sixth cranial nerve palsies (<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s) are associated with increased short\u2010 and long\u2010term risk of a subsequent stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a nationwide retrospective propensity score\u2010matched cohort study. A cohort of patients with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0466) and a randomly selected, propensity\u2010matched control cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a02281) were extracted from the Korean national insurance claim database. Subjects were tracked for 5\u00a0years total, subdivided into periods of 0\u20131\u00a0years, 1\u20133\u00a0years and 3\u20135\u00a0years. We assessed the risk of stroke using hazard ratios (<jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content>) and confidence intervals (CIs) after adjustments using Cox regression at different time intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 3.1\u00a0years. Stroke developed in 18.9% of the <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> cohort and 7.5% of the control cohort. Stroke risk after <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> was highest in the first year [14.7 per 100 person\u2010year at 0\u20131\u00a0years (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a06.6), 3.1 per 100 person\u2010year at 1\u20133\u00a0years (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.6) and 4.3 per 100 person\u2010year at 3\u20135\u00a0years (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a02.8)]. Each type of <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> was also associated with stroke risk: within 0\u20131\u00a0years, stroke risk was increased in third (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a07.6), fourth (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a06.0) and sixth (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a05. 84) <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s. In the 3\u2010 to 5\u2010year period, risk was increased in sixth (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a04.7) and fourth (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a03.3) <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s, but not third (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.6) <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients in the <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> cohort were more likely to have a stroke than those in the matched control cohort; the increased risk was both time\u2010 and cranial nerve\u2010dependent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13488","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T19:39:29Z","timestamp":1501789169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Stroke risk among adult patients with third, fourth or sixth cranial nerve palsy: a Nationwide Cohort Study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-2620","authenticated-orcid":false,"given":"Tyler Hyungtaek","family":"Rim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Severance Hospital Institute of Vision Research Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Severance Hospital Institute of Vision Research Yonsei University College of 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