{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:13:47Z","timestamp":1789172027156,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy and safety of eplerenone for chronic nonresolving central serous chorioretinopathy (<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, double\u2010blind, randomized placebo\u2010controlled study. Nineteen eyes of 17 patients with persistent subretinal fluid (<jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content>) due to <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> were enrolled and randomized to receive eplerenone 50\u00a0mg\/day or placebo for 3\u00a0months, followed by a 3\u2010month follow\u2010up. The main outcome measure was change in <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content> from baseline to 3\u00a0months of treatment. Secondary outcomes included change in <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content> at any time\u2010point, complete resolution of <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content>, improvement in choroidal thickness and change in best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen eyes were treated with eplerenone and six with placebo. Both groups showed reduction in <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content> throughout the treatment period, with a significant reduction at months 1, 3 and 5 only in the treatment group. Twenty\u2010three per cent in the treatment group and 30.8% per cent in the placebo group experienced complete resolution of <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content>. A significant improvement in <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> was noted in the placebo group at 4\u00a0months, as well as a significant difference in <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> between groups at 3\u00a0months in favour of the placebo group (p\u00a0=\u00a00.005). There was no significant difference in choroidal thickness in either group throughout the study period. No adverse events related to eplerenone were noted in the treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, eplerenone was not found to be superior to placebo in eyes with chronic <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13491","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T10:24:35Z","timestamp":1498559075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Eplerenone for chronic central serous chorioretinopathy\u2013a randomized controlled prospective study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-5713","authenticated-orcid":false,"given":"Roy","family":"Schwartz","sequence":"first","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Habot\u2010Wilner","sequence":"additional","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Nutman","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Internal Medicine Division Tel Aviv Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiri","family":"Shulman","sequence":"additional","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Guzner\u2010Gur","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Internal Medicine Division Tel Aviv Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Ophthalmology Division Tel Aviv Medical Center Tel Aviv Israel"},{"name":"The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Sydney A. 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