{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:07:32Z","timestamp":1750478852710,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zhejiang Medical science and Technology Project","award":["2014KYB272"],"award-info":[{"award-number":["2014KYB272"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to determine risk factors for retinal haemorrhage (<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) in high\u2010risk infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3123 cases with high\u2010risk pregnancy and\/or neonatal asphyxia 72\u00a0hr after delivery were enrolled into this study. Fundus examinations were performed on newborns utilizing a wide\u2010angle imaging system (RetCam III). Retinal haemorrhage (RH) was classified into three grades. Maternal, obstetric and neonatal parameters from high\u2010risk infants with<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>were compared with parameters from infants without<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retinal haemorrhage (RH) was found in 550 (18%) of 3123 high\u2010risk infants. Retinal haemorrhage (RH) was classified as grade I (39%), grade<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>(24%) and grade<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>(37%). Monocular<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>occurred in 37% of cases, while the remaining cases were binocular. Moreover, six cases had vitreous haemorrhage. The following parameters correlated (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) with<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>in this study: delivery mode (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0469), gestational age (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a035), birth weight (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a018), asphyxia (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a073), scalp hematoma (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a055), maternal age (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a08.9), precipitate labour (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0120) and delivery times (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a06.1). Logistic regression analysis indicated that delivery mode and asphyxia were risk factors for<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>in high\u2010risk infants, with odds ratios of 0.827 and 2.5, respectively. Gender, intracranial haemorrhage and foetal distress were not correlated with<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>in high\u2010risk infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>in high\u2010risk infants was 18%, and delivery mode, and neonatal asphyxia were major risk factors for<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>in high\u2010risk infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13515","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T12:26:34Z","timestamp":1499084794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Factors related to retinal haemorrhage in infants born at high risk"],"prefix":"10.1111","volume":"95","author":[{"given":"Qinglan","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Jiaxing Maternal and Child health care Hospital Jiaxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiaxing Maternal and Child health care Hospital Jiaxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiaxing Maternal and Child health care Hospital Jiaxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiaxing Maternal and Child health care Hospital Jiaxing Zhejiang 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