{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:57:21Z","timestamp":1779206241672,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015738","name":"Mary and Georg C Ehrnrooth Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Finnish Eye Foundation"},{"name":"Glaukooma Tukis\u00e4\u00e4ti\u00f6 LUX"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the long\u2010term outcome of deep sclerectomy with and without mitomycin\u2010C (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>) in patients with normal\u2010tension glaucoma (<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analysed consecutive patients randomized to surgery performed either with (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group) or without (non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>. Surgery was considered totally successful if, after surgery, the preoperative intra\u2010ocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) level was reduced by 25% without medication, and a qualified success if medication was required to achieve the same limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 patients were enrolled, 15 in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> and 22 in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group. The median (range) follow\u2010up was 7.9 (1.0\u20139.0) years, with a drop\u2010out of three (8%) patients. The preoperative <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was 15 (11\u201321) mmHg in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> and 15 (10\u201319) mmHg in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group. At the last 6\u2010 to 9\u2010year follow\u2010up, <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was significantly reduced to 9 (2\u201313) mmHg (p\u00a0=\u00a00.002) and 10 (5\u201313) mmHg (p\u00a0&lt;\u00a00.001). The overall (groups combined) complete and qualified success rates were 50% and 71%, with no significant difference between groups (p\u00a0=\u00a00.48 and p\u00a0=\u00a00.25). Goniopuncture was performed in 87% and 100% of eyes in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> groups (p\u00a0=\u00a00.14). Needling with <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> injection was performed 0 (0\u20131) times in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group and 0.5 (0\u20134) times in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.056). We encountered no cases of hyphema, shallow anterior chamber, hypotony maculopathy, choroidal effusion, late bleb leakage, blebitis, endophthalmitis or malignant glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>, long\u2010term significant <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction can be achieved with deep sclerectomy with a low incidence of sight\u2010threatening complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13529","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T11:46:37Z","timestamp":1503315997000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term results of deep sclerectomy in normal\u2010tension 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