{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:34:28Z","timestamp":1788719668194,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018Victor Babes\u2019 University of Medicine and Pharmacy of Timisoara","award":["677\/09.04.2015"],"award-info":[{"award-number":["677\/09.04.2015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to assess the macular anatomy using spectral domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>), in children born preterm who had laser\u2010treated retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>), and to investigate the relationship between structural changes in macula and visual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven 3\u20138\u00a0years old children were included in the study in two groups: 20 children born preterm [(&lt;34\u00a0weeks of gestation, birthweight (BW) &lt;2000\u00a0g)] who had laser\u2010treated <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender). Spectral domain optical coherence tomography (SD\u2010OCT) imaging (Spectralis <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) was performed at central fovea and 1\u00a0mm nasally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> group (total 34 eyes), we included both eyes in 14 children, and on one eye in six other children. In the control group, both eyes for all 17 children were included. Central fovea thickness (<jats:styled-content style=\"fixed-case\">CFT<\/jats:styled-content>) was significantly higher in children born preterm and with laser\u2010treated <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> as compared to controls (275\u00a0\u00b1\u00a034.8\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 224\u00a0\u00b1\u00a027.2\u00a0<jats:italic>\u03bc<\/jats:italic>m; p\u00a0&lt;\u00a00.001). The laser\u2010treated eyes with <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> had mean best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>)\u00a0=\u00a00.19 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> (20\/31 Snellen); 35% had <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> \u22650.3 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> (20\/40 Snellen). In receiver operating characteristic curve (ROC) analysis, with <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> as static variable (category 0\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> \u22640.3 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content>), the <jats:styled-content style=\"fixed-case\">CFT<\/jats:styled-content> cut\u2010off was 257\u00a0<jats:italic>\u03bc<\/jats:italic>m (sensitivity: 0.917; specificity: 0.661; area under the curve: 0.810, p\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Years after the laser intervention, central fovea was significantly thicker in <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> laser\u2010treated children born preterm when compared to controls. Central fovea thickness (CFT) correlated strongly and inversely with BW and gestational age (GA) at birth, while a <jats:styled-content style=\"fixed-case\">CFT<\/jats:styled-content> value above 257\u00a0<jats:italic>\u03bc<\/jats:italic>m was suggestive for suboptimal visual acuity. The proposed cut\u2010off value needs to be validated in future larger studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13536","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T13:22:42Z","timestamp":1505827362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical relevance of retinal structure in children with laser\u2010treated retinopathy of prematurity versus controls \u2013 using optical coherence tomography"],"prefix":"10.1111","volume":"96","author":[{"given":"Florina","family":"Stoica","sequence":"first","affiliation":[{"name":"Genetics Department Center of Genomic Medicine University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara Timisoara Romania"},{"name":"Neonatology Department Municipal Clinical Emergency Hospital of Timisoara Timisoara 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G.","family":"Zimbru","sequence":"additional","affiliation":[{"name":"Genetics Department Center of Genomic Medicine University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara Timisoara Romania"},{"name":"Department of Automation and Applied Informatics Faculty of Automation and Computers Politehnica University of Timisoara Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Puiu","sequence":"additional","affiliation":[{"name":"Genetics Department Center of Genomic Medicine University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara Timisoara Romania"},{"name":"Regional Center of Medical Genetics Timis Clinical Emergency Hospital for Children \u201cLouis Turcanu\u201d Timisoara Timisoara 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