{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:06:00Z","timestamp":1787051160549,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nordstr\u00f6mer Foundation"},{"name":"Foundation for the Visually Impaired in former Malm\u00f6hus County"},{"name":"Stig and Ragna Gorthon Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>Retinopathy of prematurity (ROP<\/jats:styled-content>) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP<\/jats:styled-content> is reported.<\/jats:p><\/jats:sec>Methods<\/jats:title>With the help of a Swedish register for ROP<\/jats:styled-content>, SWEDROP<\/jats:styled-content>, national and regional incidences of ROP<\/jats:styled-content> and frequencies of treatment were evaluated from 2008 to 2015 (n<\/jats:italic>\u00a0=\u00a05734), as well as before and after targets of provided oxygen changed from 85\u201389% to 91\u201395% in 2014.<\/jats:p><\/jats:sec>Results<\/jats:title>Retinopathy of prematurity (ROP) was found in 31.9% (1829\/5734) of all infants with a gestational age (GA) of <31\u00a0weeks at birth and 5.7% of the infants (329\/5734) had been treated for ROP<\/jats:styled-content>. Analyses of the national data revealed an increased incidence of ROP<\/jats:styled-content> during the 8\u2010year study period (p\u00a0=\u00a00.003), but there was no significant increase in the frequency of treatment. There were significant differences between the seven health regions of Sweden, regarding both incidence of ROP<\/jats:styled-content> and frequency of treatment (p\u00a0<\u00a00.001). Comparison of regional data before and after the new oxygen targets revealed a significant increase in treated ROP<\/jats:styled-content> in one region [OR<\/jats:styled-content>: 2.24 (CI<\/jats:styled-content>: 1.11\u20134.49), p\u00a0=\u00a00.024] and a borderline increase in one other [OR<\/jats:styled-content>: 3.08 (CI<\/jats:styled-content>: 0.99\u20139.60), p\u00a0=\u00a00.052].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The Swedish national ROP<\/jats:styled-content> register revealed an increased incidence of ROP<\/jats:styled-content> during an 8\u2010year period and significant regional differences regarding the incidence of ROP<\/jats:styled-content> and frequency of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13549","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T10:12:33Z","timestamp":1508926353000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Increased frequency of retinopathy of prematurity over the last decade and significant regional differences"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-7186","authenticated-orcid":false,"given":"Gerd","family":"Holmstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Neuroscience\/ophthalmology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Tornqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"\u200eAl\u2010Hawasi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Wallin","sequence":"additional","affiliation":[{"name":"St. Erik Eye Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience and rehabilitation Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg 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