{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:17:24Z","timestamp":1780636644682,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the corneal backward scattering and higher\u2010order aberrations (<jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s) in children with vernal keratoconjunctivitis (<jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content>) and normal topography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six eyes of 22 patients with <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> and 54 eyes of 34 normal subjects were included. All participants had clear cornea, absence of dry eyes and a normal corneal tomography. Scheimpflug imaging was used to measure corneal backward scattering in zones centred on the corneal apex (central 2\u2010mm zone and paracentral 2\u2010 to 6\u2010mm zone), and <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s were compared between <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> and normal control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of participants was 12.0\u00a0\u00b1\u00a04.1\u00a0years in <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> group and 11.2\u00a0\u00b1\u00a04.1\u00a0years in control group (p\u00a0=\u00a00.339). There was no significant intergroup difference in mean keratometry, astigmatism and apex pachymetry (p\u00a0\u2265\u00a00.076). Total corneal backscatter was higher in the <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> group compared to the control group (p\u00a0\u2264\u00a00.012). Anterior and posterior cornea displayed a higher level of backward scattering in the <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> group (p\u00a0&lt;\u00a00.001 for anterior; p\u00a0\u2264\u00a00.048 for posterior). Patients with <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> exhibited higher total <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s and coma (p\u00a0\u2264\u00a00.036). There were significant correlations between total anterior <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s and backward scattering measured at the central (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.500; p\u00a0=\u00a00.032) and paracentral zones (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.470; p\u00a0=\u00a00.024) for <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study showed optical quality changes in patients with clear corneas and quiescent <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content>. An increase in corneal backward scattering and <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s was noted in patients with <jats:styled-content style=\"fixed-case\">VKC<\/jats:styled-content> as compared to normal patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13566","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T06:22:44Z","timestamp":1509517364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Corneal backward scattering and higher\u2010order aberrations in children with vernal keratoconjunctivitis and normal topography"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-9482","authenticated-orcid":false,"given":"Tommy C. 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