{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:21:33Z","timestamp":1773030093831,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) and functional changes in the optic nerve during optic neuritis (<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>) in patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients with<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>due to<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>within 3\u00a0months of onset of symptoms were enrolled [22 females, 10 males, age 34\u00a0\u00b1\u00a09\u00a0years, median 32.5\u00a0years, 22 patients with the clinically isolated syndrome (<jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>), 10 patients with relapsing\u2010remitting from of<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>(RRMS)]. All patients were examined using optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint<jats:sup>\u00ae<\/jats:sup>, Minneapolis, MN,<jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arterio\u2010venous difference (<jats:styled-content style=\"fixed-case\">AVD<\/jats:styled-content>) was increased in patients<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>affected eye compared to patients' unaffected eye (PUE) [34.2\u00a0\u00b1\u00a04.7 versus 31.3\u00a0\u00b1\u00a04.6, p\u00a0=\u00a00.044 (mean\u00a0\u00b1\u00a0standard deviation)]. No statistically significant difference was found in vessel oxygen saturation as well as in<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>thickness in<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>affected eyes when compared to unaffected<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>eye and healthy (p\u00a0&lt;\u00a00.0001 for both comparisons). No correlation between oxygen saturation values and<jats:styled-content style=\"fixed-case\">VEP<\/jats:styled-content>was observed in patients with<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">AVD<\/jats:styled-content>in oxygen saturation is altered in patients with acute<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>. In the early stage of<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">AVD<\/jats:styled-content>could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>patients in suspicion of<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>. This result would be promising for future investigation in this field.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13571","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T10:42:37Z","timestamp":1509532957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis \u2013 a pilot study"],"prefix":"10.1111","volume":"96","author":[{"given":"Tereza","family":"Svr\u010dinov\u00e1","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital and Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mare\u0161","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital and Faculty of Medicine and Dentistry Palacky University Olomouc Czech 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