{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:57:11Z","timestamp":1781593031507,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess layer\u2010 and location\u2010specific retinal thickness deficits in autosomal dominant optic atrophy (<jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content>) using Spectralis <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 41 <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> patients with <jats:italic><jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>1<\/jats:italic> exon 28 (2826delT) mutation [age, 8.6\u201383.5\u00a0years; best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>), 8\u201389 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation\u2010free first\u2010degree relatives as healthy controls (age, 8.9\u201368.7; <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, 80\u201399).<\/jats:p><jats:p>Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>), ganglion cell layer (<jats:styled-content style=\"fixed-case\">GCL<\/jats:styled-content>), inner plexiform layer (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The perifoveal <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IPL<\/jats:styled-content> and the peripapillary <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> were all significantly thinner in <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> patients than in healthy controls (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the <jats:styled-content style=\"fixed-case\">GCL<\/jats:styled-content> (\u221249.9%) in the \u2018nasal inner macula\u2019 (NIM) sector (\u221263%). Attenuation of the peripapillary <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> was most significant in the temporal sector (\u221258.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content>, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the <jats:styled-content style=\"fixed-case\">GCL<\/jats:styled-content>, which together with the temporal peripapillary <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> area serves as the strongest diagnostic <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> marker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13588","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T13:12:35Z","timestamp":1509541955000},"page":"251-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Thickness mapping of individual retinal layers and sectors by Spectralis <scp>SD<\/scp>\u2010<scp>OCT<\/scp> in Autosomal Dominant Optic Atrophy"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-8297","authenticated-orcid":false,"given":"Nihada","family":"Corajevic","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"R\u00f6nnb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.034"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174560"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3278"},{"key":"e_1_2_5_5_1","first-page":"3","article-title":"Optic nerve head microcirculation in autosomal dominant optic atrophy and normal\u2010tension glaucoma","volume":"1335","author":"Himori N","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12999"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-46"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.06.034"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2852-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/121398"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.825296"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.2"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T14:50:23Z","timestamp":1694271023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/aos.13588"],"URL":"https:\/\/doi.org\/10.1111\/aos.13588","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}