{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:40:59Z","timestamp":1782729659537,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Foundation Rotterdam Eye Hospital"},{"name":"Foundation Dutch Ophthalmological Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized, placebo\u2010controlled superiority trial in three tertiary referral centres in the Netherlands. Patients with suspected bacterial endophthalmitis within 6\u00a0weeks after cataract surgery were eligible. A diagnostic vitreous biopsy was taken for culture, and patients received intravitreal injections of 400\u00a0<jats:italic>\u03bc<\/jats:italic>g dexamethasone (without preservatives) or placebo, in addition to 0.2\u00a0mg vancomycin and 0.05\u00a0mg gentamicin. The vancomycin and dexamethasone or placebo injections were repeated once at day 3 or 4. Primary outcome measure was best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 1 November 2004 and 1 March 2014 (excluding two interruptions totalling 20\u00a0months), 324 eligible patients presented. A total of 167 patients (81 dexamethasone, 86 placebo) were available for the intention\u2010to\u2010treat analysis. Biopsies of 114 patients (68%) were culture\u2010positive. Final <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> did not differ between the dexamethasone and the placebo group (log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> 0.31\u00a0\u00b1\u00a00.58 versus 0.27\u00a0\u00b1\u00a00.50; p\u00a0=\u00a00.90), nor did the number of patients with final vision of no light perception (LP, 7 versus 13). Pain, corneal oedema, the absence of a red fundus reflex on presentation, LP on presentation and culture of virulent pathogens from biopsy were statistically significantly associated with an unfavourable visual outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intravitreal dexamethasone without preservatives as an adjuvant to intravitreal antibiotics does not improve visual acuity (VA) in patients treated for suspected bacterial endophthalmitis after cataract surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13610","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T08:33:09Z","timestamp":1512635589000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A prospective multicentre randomized placebo\u2010controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of 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