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Peripapillary chorioretinal atrophy (PPA) area and\n PPA<\/jats:styled-content>\n superficial choroidal image intensity (\n PPA<\/jats:styled-content>\n \u2010\n CI<\/jats:styled-content>\n ) were calculated with\n image j<\/jats:sc>\n software. Clinical characteristics, laser speckle flowgraphy\u2010measured mean blur rate in the temporal tissue area (temporal\n MT<\/jats:styled-content>\n ), the central thresholds (the averaged standard automated perimetry\u2010measured visual field thresholds in the four paracentral points) and 3D\u2010\n OCT<\/jats:styled-content>\n \u2010measured ganglion cell complex thickness in the papillomacular bundle (\n PMB<\/jats:styled-content>\n \u2010\n GCCT<\/jats:styled-content>\n ) were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n NTG<\/jats:styled-content>\n patients had significantly lower intraocular pressure,\n PMB<\/jats:styled-content>\n \u2010\n GCCT<\/jats:styled-content>\n and central threshold values, and a larger\n PPA<\/jats:styled-content>\n area, than the controls. The area under the receiver operating characteristics curve to differentiate\n NTG<\/jats:styled-content>\n with parafoveal scotoma (PFS) from controls was 0.76 for temporal\n MT<\/jats:styled-content>\n , 0.85 for\n PPA<\/jats:styled-content>\n \u2010\n CI<\/jats:styled-content>\n and 0.87 for\n PMB<\/jats:styled-content>\n \u2010\n GCCT<\/jats:styled-content>\n . Univariate and multivariate analyses revealed that\n PPA<\/jats:styled-content>\n \u2010\n CI<\/jats:styled-content>\n was negatively correlated with age, pulse rate, best\u2010corrected visual acuity, axial length and\n PPA<\/jats:styled-content>\n area, and positively correlated with temporal\n MT<\/jats:styled-content>\n ,\n PMB<\/jats:styled-content>\n \u2010\n GCCT<\/jats:styled-content>\n and the central thresholds.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Peripapillary chorioretinal atrophy (PPA)\u2010\n CI<\/jats:styled-content>\n was associated with temporal\n MT<\/jats:styled-content>\n , ageing, bradycardia, axial length elongation and changes in central retinal structure and visual function in patients with\n NTG<\/jats:styled-content>\n and myopic disc. Thus, microcirculation deep within the\n PPA<\/jats:styled-content>\n zone might be a clinically useful biomarker of\n PFS<\/jats:styled-content>\n in\n NTG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.13621","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T07:56:42Z","timestamp":1511510202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal\u2010tension glaucoma with myopic disc"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-7048","authenticated-orcid":false,"given":"Naoki","family":"Kiyota","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine Sendai 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