{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:22:45Z","timestamp":1772961765730,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Previous studies report that the response of retinal vessels to a decrease in oxygen (hypoxia) is vasodilation, thus increasing blood flow. We aimed to characterize the changes in retinal microvasculature induced by a mild hypoxia stress test in a healthy population, using ocular coherence tomography angiography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\u2010A) technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interventional repeated\u2010measures study. The standardized hypoxia challenge test (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) was performed to all volunteers, according to the British\u00a0Thoracic Society protocol. Ocular coherence tomography angiography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\u2010A) was performed at three time\u2010points (baseline, during <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> and 30\u2032 posthypoxia). Macular and peripapillary vessel densities were assessed\u00a0using the built\u2010in software. To minimize bias, analysis was performed separately in right (<jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content>) and left (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) eyes. Repeated\u2010measures <jats:sc>anova<\/jats:sc> and mean comparison analysis were used as statistical tests (<jats:sc>stata<\/jats:sc> v13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Studied population included 30 healthy subjects (14 women), with a mean age of 28.8\u00a0\u00b1\u00a04.2 [range 22\u201337] years. Baseline vessel density increased in hypoxic conditions and subsequently decreased to near\u2010baseline values in posthypoxia conditions. This pattern was observed for both eyes in both parafovea (<jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content>: 55.3\u00a0\u00b1\u00a02.3 to 56.7\u00a0\u00b1\u00a01.9 to 55.8\u00a0\u00b1\u00a01.9, p\u00a0&lt;\u00a00.05; <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>: 56.9\u00a0\u00b1\u00a02.1 to 57.9\u00a0\u00b1\u00a01.9 to 57.3\u00a0\u00b1\u00a01.7, p\u00a0&lt;\u00a00.05) and peripapillary (<jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content>: 60.5\u00a0\u00b1\u00a00.5 to 62.6\u00a0\u00b1\u00a00.5 to 60.1\u00a0\u00b1\u00a00.4, p\u00a0&lt;\u00a00.05; <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>: 60.4\u00a0\u00b1\u00a00.4 to 62.3\u00a0\u00b1\u00a00.5 to 60.7\u00a0\u00b1\u00a00.4, p\u00a0&lt;\u00a00.05) areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, there are no published data specifically addressing mild hypoxia conditions and retinal microvasculature changes, using <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\u2010A. This pilot study may pave way to better understand vascular responses in disease setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13622","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T07:13:54Z","timestamp":1511248434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Hypoxia challenge test and retinal circulation changes \u2013 a study using ocular coherence tomography angiography"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7680-0325","authenticated-orcid":false,"given":"David Cordeiro","family":"Sousa","sequence":"first","affiliation":[{"name":"Ophthalmology Department Hospital de Santa Maria Lisbon Portugal"},{"name":"Vision Sciences Study Center CECV, Faculdade de Medicina, Universidade de Lisboa Lisbon 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