{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:23:27Z","timestamp":1781821407780,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (<jats:styled-content style=\"fixed-case\">LSFG<\/jats:styled-content>) or optical coherence tomography angiography (<jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 82 eyes of 82 open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">OAG<\/jats:styled-content>) patients who underwent same\u2010day <jats:styled-content style=\"fixed-case\">LSFG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content> examinations, with 20 eyes of 20 healthy subjects as controls. In <jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content> images, vessel density (<jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1.6\u2010, 3.2\u2010 and 3.6\u2010mm\u2010diameter circles around the optic nerve head (<jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content>). In R3, the large vessels were automatically masked to calculate pure capillary density (auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">LSFG<\/jats:styled-content>\u2010measured mean blur rate (<jats:styled-content style=\"fixed-case\">MBR<\/jats:styled-content>) was examined in the overall <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>), vessel\u2010area <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>) and tissue\u2010area <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> had high reproducibility (coefficient of variation: 1.65\u20133.88%) and accurately reflected manual R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> [mean bias: \u22120.0087% (auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> \u2013 manual R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>)]. <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> decreased significantly with <jats:styled-content style=\"fixed-case\">OAG<\/jats:styled-content> severity, especially in the early <jats:styled-content style=\"fixed-case\">OAG<\/jats:styled-content> stages (control vs. mild: p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003 and p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, respectively). R1 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> did not change with severity. R2 and auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> decreased significantly with <jats:styled-content style=\"fixed-case\">OAG<\/jats:styled-content> severity, especially in the severe stages (R2, mild vs. severe: p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008; auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>, mild vs. severe: p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, moderate vs. severe: p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Optical coherence tomography angiography\u2010derived auto R3 <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> is novel, reproducible and accurately reflects manual measurements. It is useful for differentiating moderate and advanced glaucoma, while <jats:styled-content style=\"fixed-case\">LSFG<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> is useful for identifying early glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13639","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T04:14:53Z","timestamp":1521951293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-7048","authenticated-orcid":false,"given":"Naoki","family":"Kiyota","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine Sendai 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