{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:25Z","timestamp":1787013865299,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Vitreoretinal (\n                      <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>\n                      ) surgery is the third most common intraocular surgery after refractive and cataract surgery. The impact of statin therapy on\n                      <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>\n                      surgery outcomes remains unclear, despite a potentially beneficial effect. We explored the association of preoperative statin therapy and the need for revitrectomy after primary vitrectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our historical, population\u2010based, register\u2010based, VR surgery cohort consisted of 5709 patients operated in a tertiary, academic referral hospital in Finland, during 2008\u20132014, covering 6.5\u00a0years.<\/jats:p>\n                    <jats:p>\n                      Subgroup analysis was performed as follows: eyes operated due to (i) rhegmatogenous retinal detachment (\n                      <jats:styled-content style=\"fixed-case\">RRD<\/jats:styled-content>\n                      ), (ii) VR interface diseases (macular pucker\/hole), (iii) diabetic maculopathy or proliferative retinopathy, (iv) vitreous haemorrhage, (v) lens subluxation, (vi) vitreous opacities or (vii) other\n                      <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>\n                      indication.\n                    <\/jats:p>\n                    <jats:p>The primary end\u2010point event was revitrectomy during a postoperative follow\u2010up period of 1\u00a0year due to retinal redetachment, vitreous rehaemorrhage, postoperative endophthalmitis, recurrent pucker or unclosed macular hole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rhegmatogenous retinal detachment (\n                      <jats:styled-content style=\"fixed-case\">RRD<\/jats:styled-content>\n                      ) was the second most frequent indication of\n                      <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>\n                      surgery, including 1916 patients, with 305 re\u2010operations with rate 0.20 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.18\u20130.23) per person\u2010year. Statin treatment in time of operation was associated with lower risk of re\u2010operation according to relative scale (incidence rate ratio 0.72, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.53\u20130.97), but not in absolute scale (incidence rate difference \u22120.58, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22124.30 to 3.15 for 100 person\u2010years). No association with statin therapy and vitrectomy outcome was observed in the other\n                      <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>\n                      subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Use of statin treatment was associated with a 28% lower risk of revitrectomy in patients operated due to\n                      <jats:styled-content style=\"fixed-case\">RRD<\/jats:styled-content>\n                      . Further randomized clinical trials are highly warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13641","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T13:11:01Z","timestamp":1516108261000},"page":"442-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Statin use and vitreoretinal surgery: Findings from a Finnish population\u2010based cohort study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-3900","authenticated-orcid":false,"given":"Sirpa","family":"Loukovaara","sequence":"first","affiliation":[{"name":"Unit of Vitreoretinal Surgery Department of Ophthalmology University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Sahanne","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Takala","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Haukka","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.09.070"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-7-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0284-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60104-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360466"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.159939"},{"key":"e_1_2_5_8_1","first-page":"12","article-title":"Rhegmatogenous retinal detachment\u2013an ophthalmologic emergency","volume":"111","author":"Feltgen N","year":"2014","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150909100212"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.12.004"},{"key":"e_1_2_5_11_1","first-page":"113","article-title":"Finnish health and social welfare registers in epidemiological research","volume":"14","author":"Gissler M","year":"2004","journal-title":"Norsk Epidemiologi"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20150730-04"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150909095237"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0664-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.04.010"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13295"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.013"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00012"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16386"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.015"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0302"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000447"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.09.024"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804054105"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2007-7"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00146-2"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306036"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.02.022"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70386j"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.8005"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029724"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.008"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/815937"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-19003"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00023-X"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.07.005"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.052"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13113"},{"key":"e_1_2_5_40_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2016"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10931"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12017"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S128746"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000306"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12752"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.12.033"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2012.663854"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.098486"},{"key":"e_1_2_5_49_1","first-page":"CD004816","article-title":"Statins for the primary prevention of cardiovascular disease","volume":"1","author":"Taylor F","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_50_1","first-page":"1","article-title":"Statin medication in patients with epiretinal membrane is associated with low intravitreal EPO, TGF\u2010beta\u20101, and VEGF levels","volume":"92","author":"Tuuminen R","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12363"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2873-2"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000657"},{"key":"e_1_2_5_54_1","unstructured":"WHOCC \u2010 ATC\/DDD Index.2012.http:\/\/www.whocc.no\/atc_ddd_index\/(accessed 11 Sep2012)."},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301988"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12327"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:10:10Z","timestamp":1694981410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/aos.13641"],"URL":"https:\/\/doi.org\/10.1111\/aos.13641","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"assertion":[{"value":"2017-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}