{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:23:14Z","timestamp":1784953394067,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010328","name":"Stichting Lijf en Leven","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010328","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Recent insights into the pathogenesis of immune\u2010mediated diseases proposed a new classification, which includes autoimmune and auto\u2010inflammatory diseases. The prevalence of specific autoimmune and auto\u2010inflammatory diseases in uveitis and\/or scleritis is not yet known. In this study, we examine the presence of systemic immune\u2010mediated diseases in patients with uveitis and\/or scleritis and put a special emphasis on autoimmune disorders by reporting on their clinical manifestations and visual prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we reviewed data of 1327 patients presenting with uveitis and\/or scleritis between January 2010 and July 2016 at the Erasmus Medical Center, Rotterdam, the Netherlands. All patients with noninfectious uveitis and\/or scleritis were classified according to novel criteria for immune\u2010mediated diseases. Various clinical data, including visual acuity (VA), of patients with uveitis of autoimmune origin were registered during 5\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The origin of uveitis was in 5% (62\/1327) autoimmune, in 15% (197\/1327) auto\u2010inflammatory and in 14% (180\/1327) mixed autoimmune\/auto\u2010inflammatory. Patients with classical autoimmune connective tissue disease (<jats:italic>N<\/jats:italic>\u00a0=\u00a017) suffered mostly from rheumatoid arthritis and granulomatosis with polyangiitis and exhibited predominantly scleritis (53%). After 5\u00a0years of follow\u2010up, none of the eyes of these patients developed legal blindness (VA of &lt;0.1). The VA in patients with uveitis associated with autoimmune neuro\u2010ophthalmological diseases (multiple sclerosis and neuromyelitis optica; <jats:italic>N<\/jats:italic>\u00a0=\u00a027) remained stable over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Uveitis and scleritis of autoimmune origin were observed in 5% of the total series. The term autoimmune uveitis should not be used as a synonym for intraocular inflammation of noninfectious origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13652","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T14:58:52Z","timestamp":1516892332000},"page":"481-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Autoimmunity in uveitis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-4991","authenticated-orcid":false,"given":"Josianne C.","family":"ten Berge","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Erasmus Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco W. J.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L. A.","family":"van Daele","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniki","family":"Rothova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.04.010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0221"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1585"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688609020048"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.02.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.4049\/jimmunol.118.3.809","article-title":"Immune response to immunization via the anterior chamber of the eye I. F. lymphocyte\u2010induced immune deviation","volume":"118","author":"Kaplan HJ","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4049\/jimmunol.120.3.689","article-title":"Immune response to immunization via the anterior chamber of the eye II. An analysis of F1 lymphocyte\u2010induced immune deviation","volume":"120","author":"Kaplan HJ","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.60"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688108998359"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0433-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181bb971b"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030297"},{"key":"e_1_2_5_15_1","first-page":"3160","article-title":"Cancer\u2010associated retinopathy induced by both anti\u2010recoverin and anti\u2010hsc70 antibodies in\u00a0vivo","volume":"40","author":"Ohguro H","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-203810"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.05.002"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90244-F"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1102574"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3414\/ME12-01-0063"},{"key":"e_1_2_5_21_1","first-page":"1","article-title":"A Focus on the Epidemiology of Uveitis","author":"Tsirouki T","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.9.1017"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.11.004"},{"key":"e_1_2_5_24_1","first-page":"955","article-title":"Experimental evidence for the role of auto\u2010immunization in chronic thyroiditis","volume":"50","author":"Witebsky E","year":"1957","journal-title":"Proc R Soc Med"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:09:07Z","timestamp":1694995747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/aos.13652"],"URL":"https:\/\/doi.org\/10.1111\/aos.13652","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]},"assertion":[{"value":"2017-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}